From patterns to patients: Advances in clinical machine learning for cancer diagnosis, prognosis, and treatment
Machine learning (ML) is increasingly used in clinical oncology to diagnose cancers, predict
patient outcomes, and inform treatment planning. Here, we review recent applications of ML …
patient outcomes, and inform treatment planning. Here, we review recent applications of ML …
Spatial mapping of cellular senescence: emerging challenges and opportunities
AU Gurkar, AA Gerencser, AL Mora, AC Nelson… - Nature aging, 2023 - nature.com
Cellular senescence is a well-established driver of aging and age-related diseases. There
are many challenges to mapping senescent cells in tissues such as the absence of specific …
are many challenges to mapping senescent cells in tissues such as the absence of specific …
[HTML][HTML] Fumarate induces vesicular release of mtDNA to drive innate immunity
V Zecchini, V Paupe, I Herranz-Montoya, J Janssen… - Nature, 2023 - nature.com
Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell
carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through …
carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through …
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …
Spatial mapping of the total transcriptome by in situ polyadenylation
Spatial transcriptomics reveals the spatial context of gene expression, but current methods
are limited to assaying polyadenylated (A-tailed) RNA transcripts. Here we demonstrate that …
are limited to assaying polyadenylated (A-tailed) RNA transcripts. Here we demonstrate that …
Distinct longevity mechanisms across and within species and their association with aging
Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …
[HTML][HTML] Lymphatics act as a signaling hub to regulate intestinal stem cell activity
Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair.
Epithelial stem cells of small and large intestines (ISCs) respond to their local …
Epithelial stem cells of small and large intestines (ISCs) respond to their local …
Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems
Whereas the cellular and molecular features of human inflammatory skin diseases are well
characterized, their tissue context and systemic impact remain poorly understood. We thus …
characterized, their tissue context and systemic impact remain poorly understood. We thus …
BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance
We developed a phenotypic screening platform for the functional exploration of dendritic
cells (DC). Here, we report a genome-wide CRISPR screen that revealed BCL2 as an …
cells (DC). Here, we report a genome-wide CRISPR screen that revealed BCL2 as an …
Performance of tumour microenvironment deconvolution methods in breast cancer using single-cell simulated bulk mixtures
Cells within the tumour microenvironment (TME) can impact tumour development and
influence treatment response. Computational approaches have been developed to …
influence treatment response. Computational approaches have been developed to …