Machine learning (ML) is increasingly used in clinical oncology to diagnose cancers, predict
patient outcomes, and inform treatment planning. Here, we review recent applications of ML …

Cellular senescence is a well-established driver of aging and age-related diseases. There
are many challenges to mapping senescent cells in tissues such as the absence of specific …

Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell
carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through …

Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …

Spatial transcriptomics reveals the spatial context of gene expression, but current methods
are limited to assaying polyadenylated (A-tailed) RNA transcripts. Here we demonstrate that …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair.
Epithelial stem cells of small and large intestines (ISCs) respond to their local …

Whereas the cellular and molecular features of human inflammatory skin diseases are well
characterized, their tissue context and systemic impact remain poorly understood. We thus …

We developed a phenotypic screening platform for the functional exploration of dendritic
cells (DC). Here, we report a genome-wide CRISPR screen that revealed BCL2 as an …

Cells within the tumour microenvironment (TME) can impact tumour development and
influence treatment response. Computational approaches have been developed to …