Eukaryotic cells face the challenging task of transporting a variety of particles through the
complex intracellular milieu in order to deliver, distribute, and mix the many components that …

The main focus in clinical proteomics is the discovery of new protein or peptide biomarkers
which are correlated with a certain disease. Tear proteins have been investigated …

Advances in the synthesis and screening of small-molecule libraries have accelerated the
discovery of chemical probes for studying biological processes. Still, only a small fraction of …

The quantification of membrane-associated biomolecular interactions is crucial to our
understanding of various cellular processes. State-of-the-art single-molecule approaches …

Exosomes are nanometer-sized vesicles, secreted by various cell types, present in
biological fluids that are particularly rich in membrane proteins. Ex vivo analysis of …

A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the
extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites …

Lysosomes are membrane-bound endocytic organelles that play a major role in degrading
cell macromolecules and recycling their building blocks. A comprehensive knowledge of the …

Membrane proteins are critical functional molecules in the human body, constituting more
than 30% of open reading frames in the human genome. Unfortunately, a myriad of …

Cell lysis is an essential step in many studies related to biology and medicine. Based on the
scale and medium that cell lysis is carried out, there are three main types of the cell lysis:(1) …

Membrane proteomics, the large-scale global analysis of membrane proteins, is often
constrained by the efficiency of separating and extracting membrane proteins. Recent …