In the 20th century, the development, licensing and implementation of vaccines as part of
large, systematic immunization programs started to address health inequities that existed …

SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …

The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …

Antibiotic resistance spreads among bacteria through horizontal transfer of antibiotic
resistance genes (ARGs). Here, we set out to determine predictive features of ARG transfer …

ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …

Infections due to multidrug-resistant Enterobacteriaceae have become major international
public health problem due to the inadequate treatment options and the historically lagged …

Hypervirulence and carbapenem resistance have emerged as two distinct evolutionary
directions for Klebsiella pneumoniae, which pose a great threat in clinical settings. Multiple …

Инфекционные заболевания во всем мире входят в десятку самых распространенных
причин смертности и являются ведущим фактором, обусловливающим годы жизни …

Escherichia coli is the most researched microbial organism in the world. Its varied impact on
human health, consisting of commensalism, gastrointestinal disease, or extraintestinal …

At 2.8 million infections due to AR pathogens and 35,900 attributable deaths each year (2),
AR is still a very real problem in the United States. Given that sicker patients not only tend to …