Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …

This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

ATP acts as a humoral mediator to control cell function extracellularly. The receptors that
mediate the actions of ATP belong to two classes, the metabotropic P2Y receptors and the …

There are seven P2X receptor cDNAs currently known. Six homomeric (P2X1, P2X2, P2X3,
P2X4, P2X5, P2X7) and three heteromeric (P2X2/P2X3, P2X4/P2X6, P2X1/P2X5) P2X …

P2X receptors are a distinct family of ligand-gated ion channels activated by extracellular
ATP. Each of the seven identified subunit proteins (P2X 1 through P2X 7) has been reported …

ATP functions as a fast neurotransmitter through the specific activation of a family of ligand-
gated ion channels termed P2X receptors. In this report, six distinct recombinant P2X …

Significant progress in understanding the pharmacological characteristics and physiological
importance of homomeric and heteromeric P2X channels has been achieved in recent …

The current status of ligand gated ion channel P2X and G protein-coupled P2Y receptor
subtypes is described. This is followed by a summary of what is known of the distribution and …