The role of tumor microenvironment cells in colorectal cancer (CRC) cachexia

A Kasprzak - International journal of molecular sciences, 2021 - mdpi.com
Cancer cachexia (CC) is a multifactorial syndrome in patients with advanced cancer
characterized by weight loss via skeletal-muscle and adipose-tissue atrophy, catabolic …

Roles for macrophage-polarizing interleukins in cancer immunity and immunotherapy

K Mortezaee, J Majidpoor - Cellular Oncology, 2022 - Springer
Macrophages are the most abundant and one of the most critical cells of tumor immunity.
They provide a bridge between innate and adaptive immunity through releasing cytokines …

Cost-effective and disposable label-free voltammetric immunosensor for sensitive detection of interleukin-6

R Cancelliere, A Di Tinno, AM Di Lellis… - Biosensors and …, 2022 - Elsevier
IL-6 detection is highly desirable since can monitor many diseases in humans and assess
the response to treatments. Herein, two novel label-free voltammetric immunosensors for …

The role of inflammatory mediators in colorectal cancer hepatic metastasis

L Goodla, X Xue - Cells, 2022 - mdpi.com
Colorectal cancer (CRC) is the second leading cause of death in cancer patients in the USA,
whereas the major cause of CRC deaths is hepatic metastases. The liver is the most …

Dynamic roles of inflammasomes in inflammatory tumor microenvironment

JH Jang, DH Kim, YJ Surh - NPJ Precision Oncology, 2021 - nature.com
The inflammatory tumor microenvironment has been known to be closely connected to all
stages of cancer development, including initiation, promotion, and progression. Systemic …

Checkpoint inhibitor/interleukin‐based combination therapy of cancer

K Mortezaee, J Majidpoor - Cancer medicine, 2022 - Wiley Online Library
Background Immunotherapy using immune checkpoint inhibitors (ICIs) is the current focus in
cancer immunotherapy. However, issues are raised in the area, as the recent studies …

[PDF][PDF] Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway

X Wei, J Ye, Y Pei, C Wang, H Yang… - Journal of …, 2022 - Wiley Online Library
Pattern‐recognition receptors (PRRs) have been shown to promote tumour metastasis via
sensing tumour cell‐derived small extracellular vesicles (EVs). Nucleotide‐binding …

The therapeutic potential of tackling tumor-induced dendritic cell dysfunction in colorectal cancer

B Subtil, A Cambi, DVF Tauriello… - Frontiers in …, 2021 - frontiersin.org
Colorectal cancer (CRC) is the third most diagnosed malignancy and the second leading
cause of cancer-related deaths worldwide. Locally advanced and metastatic disease exhibit …

A potential role of IL-6/IL-6R in the development and management of colon cancer

M Turano, F Cammarota, F Duraturo, P Izzo… - Membranes, 2021 - mdpi.com
Colorectal cancer (CRC) is the third most frequent cancer worldwide and the second
greatest cause of cancer deaths. About 75% of all CRCs are sporadic cancers and arise …

Mechanisms of immunosuppression in colorectal cancer

Y Zhang, A Rajput, N Jin, J Wang - Cancers, 2020 - mdpi.com
Simple Summary More emerging studies are exploring immunotherapy for solid cancers,
including colorectal cancer. Besides, checkpoint blockade immunotherapy and chimeric …