Chronic illnesses rarely present in a vacuum, devoid of other complications, and chronic
kidney disease is hardly an exception. Comorbidities associated with chronic kidney …

Diabetes is associated with a strongly elevated risk of cardiovascular disease, which is even
more pronounced in patients with diabetic nephropathy. Currently available guideline-based …

Na+-dependent phosphate cotransporters NaPi-IIa and NaPi-IIc, located at the brush-border
membrane of renal proximal tubules, are regulated by numerous factors, including fibroblast …

Chronic kidney disease (CKD) is a global health issue with a rising prevalence, affecting
697.5 million people worldwide. It imposes a substantial burden, contributing to 35.8 million …

Sirtuins are a family of NAD+ III-dependent histone deacetylases that consists of seven
family members, Sirt1-Sirt7, which regulate various signalling pathways and are involved in …

Clinical evidence highlights a relationship between the blood and the bone, but the
underlying mechanism linking these two tissues is not fully elucidated. Here, we used β …

Introduction Osteoporosis, a disease of reduced bone mass and microstructural
deterioration leading to fragility fractures, is becoming more prevalent as aging progresses …

Background In the past decade, fibroblast growth factor 23 (FGF23) has been recognized as
an important biomarker of cardiovascular diseases. This study aimed to assess the …

(1) Background: Preclinical and clinical studies on the anti-aging effect of α-Klotho are
emerging. Urinary albumin excretion (UAE) is a well-known biomarker of kidney injury and …

Iron deficiency is a potent stimulator of fibroblast growth factor 23 (FGF23), a hormonal
regulator of phosphate and vitamin D metabolism, that is classically thought to be produced …