[HTML][HTML] The Gastrointestinal Microbiota as a Potential Cause and Target in Chronic Kidney Disease Accentuating Treatment and Intervention Strategies

A Zupcic, P Slezak, J Radloff - Applied Sciences, 2023 - mdpi.com
Dysbiosis and impaired gastrointestinal barrier function have emerged as potential chronic
kidney disease (CKD) modulators. Accumulation of gut-derived uremic toxins, a subsequent …

[HTML][HTML] Fibroblast Growth Factor 23 Signaling Does Not Increase Inflammation from Pseudomonas aeruginosa Infection in the Cystic Fibrosis Bronchial Epithelium

MJ Hirsch, EL Matthews, S Bollenbecker, M Easter… - Medicina, 2023 - mdpi.com
Background and Objectives: Chronic inflammation due to Pseudomonas aeruginosa (PA)
infection in people with cystic fibrosis (CF) remains a concerning issue in the wake of …

[HTML][HTML] Fibroblast growth factor 23: translating analytical improvement into clinical effectiveness for tertiary prevention in chronic kidney disease

S Ferraro, G Biganzoli, V Calcaterra… - Clinical Chemistry and …, 2022 - degruyter.com
Objectives Fibroblast growth factor 23 (FGF23) plays a key role in the pathophysiology of
chronic kidney disease (CKD) and of the associated cardiovascular diseases, ranking on the …

Development of a quantitative systems pharmacology model of chronic kidney disease: metabolic bone disorder

AE Gaweda, DE McBride… - American Journal of …, 2021 - journals.physiology.org
Chronic kidney disease mineral bone disorder (CKD-MBD) is a virtually universal
complication of kidney diseases, starting early in the course of disease and resulting in …

Effects of EOS789, a novel pan-phosphate transporter inhibitor, on phosphate metabolism: Comparison with a conventional phosphate binder

K Tanifuji, Y Shiozaki, M Koike, M Uga… - The Journal of Medical …, 2023 - jstage.jst.go.jp
Background: Inorganic phosphate (Pi) binders are the only pharmacologic treatment
approved for hyperphosphatemia. However, Pi binders induce the expression of intestinal Pi …

SFN promotes renal fibrosis via binding with MYH9 in chronic kidney disease

F Wang, X Suo, J Wang, C Liu, C Liu, C Wang… - European Journal of …, 2024 - Elsevier
Chronic kidney disease (CKD) is a clinical syndrome characterized by persistent renal
function decline. Renal fibrosis is the main pathological process in CKD, but an effective …

Cardiovascular health in pediatric patients with X-linked hypophosphatemia under two years of burosumab therapy

A Brener, R Cleper, G Baruch, E Rothschild… - Frontiers in …, 2024 - frontiersin.org
Introduction X-linked hypophosphatemia (XLH) is caused by an inactivating mutation in the
phosphate-regulating endopeptidase X-linked (PHEX) gene whose defective product fails to …

Novel Perspectives in Chronic Kidney Disease-Specific Cardiovascular Disease

C Xu, G Tsihlis, K Chau, K Trinh, NM Rogers… - International Journal of …, 2024 - mdpi.com
Chronic kidney disease (CKD) affects> 10% of the global adult population and significantly
increases the risk of cardiovascular disease (CVD), which remains the leading cause of …

[HTML][HTML] Phosphorus restriction changes the expression of fibroblast growth factor 23 and its receptors in laying hens

Z Ren, J Yan, Q Hu, X Liu, C Pan, Y Liu… - Frontiers in …, 2020 - frontiersin.org
Dietary phosphorus oversupply wastes non-renewable natural resources and raises
environmental concerns in animal agriculture. We hypothesized that laying hens do not …

[HTML][HTML] Methodology and baseline data of a comparative exploratory double-blinded randomized study of intravenous iron on fibroblast growth factor 23 and …

X Kassianides, S Bhandari - Kidney and Blood Pressure Research, 2023 - karger.com
Modern intravenous iron compounds (eg, ferric carboxymaltose [FCM] and ferric
derisomaltose [FDI]) are utilized in the treatment of iron deficiency anemia in non-dialysis …