Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Endothelial cells (ECs) are sentinels of cardiovascular health. Their function is reduced by
the presence of cardiovascular risk factors, and is regained once pathological stimuli are …

Biological entities are involved in intricate and complex interactions, in which uncovering the
biological information from the network concepts are of great significance. Benefiting from …

Cancer is a major stress for public well‐being and is the most dreadful disease. The models
used in the discovery of cancer treatment are continuously changing and extending toward …

Second brain, forgotten organ, individual's identity card, and host's fingerprint are the few
collective terms that are often used to describe the gut microbiome because of its variability …

Life expectancy has gradually grown over the last century. This has deeply affected
healthcare costs, since the growth of an aging population is correlated to the increasing …

Significance: Hypertension has major health consequences, which is associated with
endothelial dysfunction. Endothelial nitric oxide synthase (eNOS)-produced nitric oxide (NO) …

Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-
1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a …

Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary artery
pressure and vascular resistance, typically leading to right heart failure and death. Current …

The prevalence and mortality rates of cardiovascular diseases are increasing, and new
treatment strategies are urgently needed. From the perspective of basic pathogenesis, the …