Ions and RNA folding
DE Draper, D Grilley, AM Soto - Annu. Rev. Biophys. Biomol …, 2005 - annualreviews.org
▪ Abstract The problem of how ions influence the folding of RNA into specific tertiary
structures is being addressed from both thermodynamic (by how much do different salts …
structures is being addressed from both thermodynamic (by how much do different salts …
Metal ions and RNA folding: a highly charged topic with a dynamic future
SA Woodson - Current opinion in chemical biology, 2005 - Elsevier
Metal ions are required to stabilize RNA tertiary structure and to begin the folding process.
How different metal ions enable RNAs to fold depends on the electrostatic potential of the …
How different metal ions enable RNAs to fold depends on the electrostatic potential of the …
The catalytic diversity of RNAs
MJ Fedor, JR Williamson - Nature reviews Molecular cell biology, 2005 - nature.com
The natural RNA enzymes catalyse phosphate-group transfer and peptide-bond formation.
Initially, metal ions were proposed to supply the chemical versatility that nucleotides lack. In …
Initially, metal ions were proposed to supply the chemical versatility that nucleotides lack. In …
Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap …
K Hara, FI Schmidt, M Crow, GG Brownlee - Journal of virology, 2006 - Am Soc Microbiol
The RNA-dependent RNA polymerase of influenza virus is a heterotrimer formed by the
PB1, PB2, and PA subunits. Although PA is known to be required for polymerase activity, its …
PB1, PB2, and PA subunits. Although PA is known to be required for polymerase activity, its …
Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site
The Tetrahymena intron is an RNA catalyst, or ribozyme. As part of its self-splicing reaction,
this ribozyme catalyzes phosphoryl transfer between guanosine and a substrate RNA …
this ribozyme catalyzes phosphoryl transfer between guanosine and a substrate RNA …
[图书][B] A fine-tuned universe: The quest for God in science and theology
AE McGrath - 2009 - kclpure.kcl.ac.uk
Exploring a wide range of physical and biological phenomena and drawing on the latest
research in biochemistry and evolutionary biology, McGrath draws out the implications of our …
research in biochemistry and evolutionary biology, McGrath draws out the implications of our …
Structural evidence for a two-metal-ion mechanism of group I intron splicing
MR Stahley, SA Strobel - Science, 2005 - science.org
We report the 3.4 angstrom crystal structure of a catalytically active group I intron splicing
intermediate containing the complete intron, both exons, the scissile phosphate, and all of …
intermediate containing the complete intron, both exons, the scissile phosphate, and all of …
From nucleotides to ribozymes—a comparison of their metal ion binding properties
E Freisinger, RKO Sigel - Coordination Chemistry Reviews, 2007 - Elsevier
It is undisputable that the fates of metal ions and nucleic acids are inescapably interwoven.
Metal ions are essential for charge compensation of the negatively charged phosphate …
Metal ions are essential for charge compensation of the negatively charged phosphate …
Charge density of divalent metal cations determines RNA stability
RNA molecules are exquisitely sensitive to the properties of counterions. The folding
equilibrium of the Tetrahymena ribozyme is measured by nondenaturing gel electrophoresis …
equilibrium of the Tetrahymena ribozyme is measured by nondenaturing gel electrophoresis …
Molecular mechanisms of enzyme activation by monovalent cations
DW Gohara, E Di Cera - Journal of Biological Chemistry, 2016 - ASBMB
Regulation of enzymes through metal ion complexation is widespread in biology and
underscores a physiological need for stability and high catalytic activity that likely predated …
underscores a physiological need for stability and high catalytic activity that likely predated …