Our understanding of allergic contact dermatitis mechanisms has progressed over the past
decade. Innate immune cells that are involved in the pathogenesis of allergic contact …

Eosinophils are bone marrow-derived granulocytes that are traditionally associated with
type 2 immune responses, such as those that occur during parasite infections and allergy …

Eosinophils are well recognized as effector cells of type 2 immunity, yet they also
accumulate in many tissues under homeostatic conditions. However, the processes that …

Eosinophil recruitment is a pathological hallmark of many allergic and helminthic diseases.
Here, we investigated chemokine receptor CCR3-induced eosinophil recruitment in …

In the vertebrate immune system, thymus stromal microenvironments support the generation
of αβT cells from immature thymocytes. Thymic epithelial cells are of particular importance …

Eosinophils are involved in host protection against multicellular organisms. However, their
recruitment to the mesenteric lymph node (mLN) during type 2 immunity is understudied. Our …

Psoriasis is a chronic inflammatory skin disease occurring worldwide. Initially viewed as a
keratinocyte disorder, psoriasis is now recognized to involve a complex interplay between …

Asthma affects 25 million Americans, and recent advances in treatment are effective for only
a portion of severe asthma patients. TREM-1, an innate receptor that canonically amplifies …

Eosinophils, traditionally associated as central innate effector cells with type-2 immunity
during allergic and helminth parasitic diseases, have recently been revealed to have …

Traditionally, eosinophils have been linked to parasitic infections and pathological disease
states. However, emerging literature has unveiled a more nuanced and intricate role for …