The necessity of understanding the detailed mechanism of flap dynamics in designing HIV-1
protease inhibitors is immense. Crystal structures have provided us with a static overview of …

HIV-1 protease performs a vital step in the propagation of the HIV virus and is therefore an
important drug target in the treatment of AIDS. It consists of a homodimer, with access to the …

Acquired immunodeficiency syndrome (AIDS) caused by the retrovirus human
immunodeficiency virus (HIV) has become a major epidemic afflicting mankind. The Joint …

Most functional processes of proteins involve significant conformational changes. In those
activated processes, the system needs to cross an energy barrier. A comprehensive …

HIV-1 protease (HIVp) inhibitors are essential for current AIDS treatments, and new
compounds are still a very active area of research. The conformational behavior of the flap …

Biochemical experiments have recently revealed that the p-S8 peptide, with an amino-acid
sequence identical to the conserved fragment 83–93 (S8) of the HIV-1 protease, can inhibit …

We have obtained the 1.7 Å crystal structure of FIV protease (PR) in which 12 critical
residues around the active site have been substituted with the structurally equivalent …

HIV‐1 protease (HIV PR) is considered as one of the most attractive targets for the treatment
of HIV and the impact of flap dynamics of HIV PR on the binding affinities of protease …

Acquired immunodeficiency syndrome (AIDS) spread by the human immunodeficiency virus
(HIV) has become an epidemic worldwide (Sanou et al., 2012). In 2016, it is assessed that …

Retroviruses are a growing concern for the health of human beings, and one of the
dangerous members of this family is the Human T-cell Leukemia Virus 1 (HTLV-1) virus. It …