Future appeal of comparative studies on putative binding sites of HIV-1 virus-encoded proteolytic enzyme inhibitor of different Food and Drug Administration-approved …
Z Abduljaleel, M Athar, F Al-Allaf… - HIV & AIDS Review …, 2020 - termedia.pl
Results The binding mode analysis showed that the active site was present at the interface
of two chains A and B of the enzyme and the crucial amino acid remained responsible for …
of two chains A and B of the enzyme and the crucial amino acid remained responsible for …
Molecular dynamics simulations of HIV-1 protease complexed with saquinavir
SJ Watson - 2009 - discovery.ucl.ac.uk
Inhibition of the Human Immunode ficiency virus type-1 (HIV-1) protease enzyme blocks
HIV-1 replication. Protease inhibitor drugs have successfully been used as a therapy for HIV …
HIV-1 replication. Protease inhibitor drugs have successfully been used as a therapy for HIV …
[PDF][PDF] Studies towards the development of novel HIV-1 integrase inhibitors
YC Lee - 2009 - core.ac.uk
The project has focused on the preparation of several series of compounds designed as
potential HIV-1 integrase inhibitors. Various 2-nitrobenzaldehydes have been reacted with …
potential HIV-1 integrase inhibitors. Various 2-nitrobenzaldehydes have been reacted with …
Crystallographic analysis and molecular modeling studies of HIV-1 protease and drug resistant mutants
CH Shen - 2014 - scholarworks.gsu.edu
Abstract HIV-1 protease (PR) is an effective target protein for drugs in anti-retroviral therapy
(ART). Using PR inhibitors (PIs) in clinical therapy successfully reduces mortality of HIV …
(ART). Using PR inhibitors (PIs) in clinical therapy successfully reduces mortality of HIV …
[PDF][PDF] Computer-aided identification of the binding sites of protein-ligand complexes
M Lumipuu - 2013 - erepo.uef.fi
The foundation of drug development is the best possible knowledge of the drugs functional
target. In order to be able to study the functional target of a drug, it is crucial to know the …
target. In order to be able to study the functional target of a drug, it is crucial to know the …
[图书][B] Lipid and Protein Contributions to Viral Proliferation as Studied Using MD Simulations and Advanced MD Techniques
JM Gardner - 2019 - search.proquest.com
HIV infection is a continuing public health crisis with more than 36 million people living with
HIV/AIDS and about 1.8 million people newly infected in 2017. Continuous research efforts …
HIV/AIDS and about 1.8 million people newly infected in 2017. Continuous research efforts …
[PDF][PDF] Novel fluorescent cell-based sensors for detection of viral pathogens
C da Silva Carreira - 2018 - run.unl.pt
Diseases caused by viruses are responsible for millions of deaths worldwide. However,
viruses are used for development of virus-based biopharmaceuticals (VBBs), like vaccines …
viruses are used for development of virus-based biopharmaceuticals (VBBs), like vaccines …
[图书][B] Molecular dynamics simulation studies of drug resistance in HIV-1 protease
SKSA Sadiq - 2008 - search.proquest.com
Overcoming the emergence of drug resistance in HIV is a major challenge to the scientific
community. We use the established computational method of classical molecular dynamics …
community. We use the established computational method of classical molecular dynamics …
[PDF][PDF] Molecular dynamics study of HIV-1 protease inhibitors and their effects on the flap dynamics of the HIV-1 subtype-C (C-SA).
SI Maphumulo - 2018 - core.ac.uk
The aspartyl protease human immunodeficiency virus type 1 (HIV-1) is a 99-amino acid-long
homodimer responsible for processing the Gag and Gag-Pol polyproteins into functional …
homodimer responsible for processing the Gag and Gag-Pol polyproteins into functional …