The enhanced antitumor activity of bispecific antibody targeting PD-1/PD-L1 signaling

T Li, M Niu, J Zhou, K Wu, M Yi - Cell Communication and Signaling, 2024 - Springer
The programmed cell death 1 (PD-1) signaling pathway, a key player in immune checkpoint
regulation, has become a focal point in cancer immunotherapy. In the context of cancer …

Expression of PD-1 and PD-L1 in Endometrial Cancer: Molecular and Clinical Significance

MN Mamat@ Yusof, KT Chew, NC Kampan… - International journal of …, 2023 - mdpi.com
The landscape of diagnosing and treating endometrial cancer is undergoing a profound
transformation due to the integration of molecular analysis and innovative therapeutic …

Mononuclear cell composition and activation in blood and mucosal tissue of eosinophilic esophagitis

E Gruden, M Kienzl, D Ristic, O Kindler… - Frontiers in …, 2024 - frontiersin.org
Introduction Eosinophilic esophagitis (EoE) is a chronic, inflammatory, antigen-driven
disease of the esophagus. Tissue EoE pathology has previously been extensively …

Endocrine side effects in patients treated with immune checkpoint inhibitors: a narrative review

NI Profili, R Castelli, A Gidaro, A Merella… - Journal of Clinical …, 2023 - mdpi.com
Checkpoint inhibitors are monoclonal antibodies that elicit an anti-tumor response by
stimulating immune system. Their use has improved the treatment of different types of cancer …

Regulation of PD-L1 Expression by YY1 in Cancer: Therapeutic Efficacy of Targeting YY1

A Dillen, I Bui, M Jung, S Agioti, A Zaravinos… - Cancers, 2024 - mdpi.com
Simple Summary We have recently witnessed several milestones in the treatment of various
cancers with immunotherapy through modulating the activity of the immune system to …

Can sPD-1 and sPD-L1 Plasma Concentrations Predict Treatment Response among Patients with Extraparenchymal Neurocysticercosis?

A Toledo, G Fragoso, R Carrillo-Mezo, ML Romo… - Pathogens, 2023 - mdpi.com
Extraparenchymal neurocysticercosis (EP-NC) is a chronic, potentially life-threatening
disease that responds poorly to initial anthelmintic drug therapy. A depressed specific …

Comprehensive Co-Inhibitory Receptor (Co-IR) Expression on T Cells and Soluble Proteins in Rheumatoid Arthritis

CM Wang, YJ Jan Wu, LY Huang, JW Zheng, JY Chen - Cells, 2024 - mdpi.com
Co-inhibitory receptors (Co-IRs) are essential in controlling the progression of
immunopathology in rheumatoid arthritis (RA) by limiting T cell activation. The objective of …

Regulation of Treg cells by cytokine signaling and co-stimulatory molecules

Y Zong, K Deng, WP Chong - Frontiers in Immunology, 2024 - frontiersin.org
CD4+ CD25+ Foxp3+ regulatory T cells (Tregs), a vital component of the immune system,
are responsible for maintaining immune homeostasis and preventing excessive immune …

Delving into the Metabolism of Sézary Cells: A Brief Review

C Cherfan, A Chebly, HR Rezvani, M Beylot-Barry… - Genes, 2024 - mdpi.com
Primary cutaneous lymphomas (PCLs) are a heterogeneous group of lymphoproliferative
disorders caused by the accumulation of neoplastic T or B lymphocytes in the skin. Sézary …

PD-1 blockade immunotherapy as a successful rescue treatment for disseminated adenovirus infection after allogeneic hematopoietic stem cell transplantation

F Zhou, F Du, Z Wang, M Xue, D Wu, S Chen… - Journal of Hematology & …, 2024 - Springer
Disseminated adenovirus infection is a complication with a relatively high mortality rate
among patients undergoing hematopoietic stem cell transplantation. The low efficacy and …