Cancer vaccines aim to direct the immune system to eradicate cancer cells. Here we review
the essential immunologic concepts underpinning natural immunity and highlight the …

Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

Exosomal circRNA serves a novel genetic information molecule, facilitating communication
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …

B cells occupy a vital role in the functioning of the immune system, working in tandem with T
cells to either suppress or promote tumor growth within the tumor microenvironment (TME) …

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

It is poorly understood how different cells in a tissue organize themselves to support tissue
functions. We describe the CytoCommunity algorithm for the identification of tissue cellular …

Neutrophils, the most prevalent innate immune cells in humans, have garnered significant
attention in recent years due to their involvement in cancer progression. This comprehensive …

Characterizing the compositional and phenotypic characteristics of tumor-infiltrating B cells
(TIBs) is important for advancing our understanding of their role in cancer development …

Background Changes in cell-type composition of tissues are associated with a wide range of
diseases and environmental risk factors and may be causally implicated in disease …

Malignant T lymphocyte proliferation in mycosis fungoides (MF) is largely restricted to the
skin, implying that malignant cells are dependent on their specific cutaneous tumor …