Colorectal cancer (CRC) is a predominant malignancy worldwide, being the fourth most
common cause of mortality and morbidity. The CRC incidence in adolescents, young adults …

In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …

Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

Porphyromonas gingivalis (P. gingivalis) is a keystone periodontal pathogen associated with
various digestive cancers. However, whether P. gingivalis can promote colorectal cancer …

The interdependence between thyroid hormones (THs), namely, thyroxine and
triiodothyronine, and immune system is nowadays well-recognized, although not yet fully …

Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …

Recent studies have revealed novel forms of cell death beyond the canonical types of
cellular apoptosis and necrosis, and these novel forms of cell death are induced by extreme …

Abstract The NLRP3-IL-1β pathway plays an important role in adipose tissue (AT)-induced
inflammation and the development of obesity-associated comorbidities. We aimed to …

Chronic kidney disease (CKD) is characterized by inflammation, injury and fibrosis.
Dysregulated innate immune responses mediated by macrophages play critical roles in …

A diet rich in saturated fat and carbohydrates causes low-grade chronic inflammation in
several organs, including the liver, ultimately driving nonalcoholic steatohepatitis. In this …