Amyloid fibrils have traditionally been considered only as pathological aggregates in human
neurodegenerative diseases, but it is increasingly becoming clear that the propensity to form …

Highlights•Cryo-EM may be used to determine atomic structures of amyloid filaments
extracted from human brain tissue.•Unique protofilament folds characterise tau filaments …

This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …

Parkinson's disease is a progressive neuropathological disorder that belongs to the class of
synucleinopathies, in which the protein alpha-synuclein is found at abnormally high …

Fibrillar aggregates of the amyloid-β protein (Aβ) are the main component of the senile
plaques found in brains of patients with Alzheimer's disease (AD). Development of probes …

Assembly of microtubule-associated protein tau into filamentous inclusions underlies a
range of neurodegenerative diseases. Tau filaments adopt different conformations in …

Abstract α-Synuclein (α-syn) amyloid fibrils are the major component of Lewy bodies, which
are the pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. High …

Abstract Staining with Congo Red (CR) is a qualitative method used for the identification of
amyloids in vitro and in tissue sections. However, the drawbacks and artefacts obtained …

The formation of Aβ amyloid fibrils is a neuropathological hallmark of Alzheimer's disease
and cerebral amyloid angiopathy. However, the structure of Aβ amyloid fibrils from brain …

Nucleation of new peptide and protein aggregates on the surfaces of amyloid fibrils of the
same peptide or protein has emerged in the past two decades as a major pathway for both …