Simple Summary The mitogen-activated protein kinase/extracellular signal-regulated kinase
(MAPK/ERK) signaling pathway is frequently activated in liver cancer, which is one of the …

Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Anlotinib is a new, orally administered tyrosine kinase inhibitor that targets vascular
endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet …

Low back pain (LBP) is a major reason for disability, and symptomatic intervertebral disc
(IVD) degeneration (IDD) contributes to roughly 40% of all LBP cases. Current treatment …

Cancer is currently the second leading cause of death globally and is expected to be
responsible for approximately 9.6 million deaths in 2018. With an unprecedented …

Hepatocellular carcinoma (HCC) is swiftly increasing in prevalence globally with a high
mortality rate. The progression of HCC in patients is induced with advanced fibrosis, mainly …

Natural products play a critical role in the discovery and development of numerous drugs for
the treatment of various types of cancer. These phytochemicals have demonstrated anti …

Natural or synthetic chalcones with different substituents have revealed a variety of
biological activities that may benefit human health. The underlying mechanisms of action …

Aptamers, synthetic single-strand oligonucleotides that are similar in function to antibodies,
are promising as therapeutics because of their minimal side effects. However, the stability …

The development of multidrug resistance (MDR) to chemotherapy remains a major
challenge in the treatment of cancer. Numerous mechanisms have been recognized that …