Small molecule receptor tyrosine kinase inhibitors (SM-TKIs) are among a group of targeted
cancer therapies, intended to be more specific to cancer cells compared with treatments …

The inhibition of cyclin dependent kinases 4 and 6 plays a role in aromatase inhibitor
resistant metastatic breast cancer. Three dual CDK4/6 inhibitors have been approved for the …

Fibroblast growth factor receptors (FGFRs) in response to fibroblast growth factors (FGFs)
transmit signals across the cell membrane, regulating important cellular processes, like …

Cancer cells have unlimited replicative potential, insensitivity to growth-inhibitory signals,
evasion of apoptosis, cellular stress, and sustained angiogenesis, invasiveness and …

Ror2 is a signaling receptor for Wnt ligands that is known to play important roles in limb
development, but having no essential roles known in adult tissues. Recent evidence has …

Anticancer drug gefitinib causes inflammation-based side effects, such as interstitial
pneumonitis. However, its mechanisms remain unknown. Here, we provide evidence that …

Vascular endothelial growth factor receptor (VEGFR) is a very important receptor tyrosine
kinase (RTK) that can induce angiogenesis, increase cell growth and metastasis, reduce …

Non-small cell lung cancer (NSCLC) with oncogenic driver mutations such as EGFR or ALK
has a high predilection for brain metastases (BMs) compared to unselected patients …

Resistance to chemotherapy agents is a major challenge infront of cancer patient treatment
and researchers. It is known that several factors, such as multidrug resistance proteins and …

Several modern treatment strategies have been adopted to combat cancer with the aim of
minimizing toxicity. Medicinal plant‐based compounds with the potential to treat cancer have …