In this paper, we described the synthesis and cytotoxic activities of two new series of thieno
[2, 3-d] pyrimidine and thieno [3, 2-d] pyrimidine derivatives. Most of the synthesized …

Quinoxaline derivatives, also called benzopyrazines, are an important class of heterocyclic
compounds. Quinoxalines have drawn great attention due to their wide spectrum of …

Kinase inhibitors are attractive drugs/drug candidates for the treatment of cancer. The most
recent literature has highlighted the importance of multi target kinase inhibitors, although a …

The introduction of the tyrosine kinase inhibitor (TKI) imatinib 15 years ago has radically
changed the treatment of advanced/metastatic gastrointestinal stroma tumours (GIST). This …

Ovarian cancer is one of the most lethal gynaecological malignancies worldwide. Despite
high success rates following first time treatment, this heterogenous disease is prone to …

The receptor tyrosine kinase ROR1 is absent in most normal adult tissues, but
overexpressed in several malignancies. In this study, we explored clinical and functional …

Brain metastases (BMs) will develop in a large proportion of patients with NSCLC
throughout the course of their disease. Among patients with NSCLC with oncogenic drivers …

Proteolysis‐targeting chimeras (PROTACs) provide a powerful technique to degrade
targeted proteins utilizing the cellular ubiquitin‐proteasome system. The major concern is …

Transmembrane receptor tyrosine kinases (RTKs) play crucial roles in cancer cell
proliferation, survival, migration and differentiation. Area of intense research is searching for …

Summary c-Kit is a classic proto-oncogene either mutated or upregulated in cancer cells,
and this leads to its constitutive kinase activation and, thus, to uncontrolled proliferation …