Mechanisms linking social media use to adolescent mental health vulnerability
Research linking social media use and adolescent mental health has produced mixed and
inconsistent findings and little translational evidence, despite pressure to deliver concrete …
inconsistent findings and little translational evidence, despite pressure to deliver concrete …
Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations
A Capalbo, G de Wert, H Mertes… - Human reproduction …, 2024 - academic.oup.com
BACKGROUND The genetic composition of embryos generated by in vitro fertilization (IVF)
can be examined with preimplantation genetic testing (PGT). Until recently, PGT was limited …
can be examined with preimplantation genetic testing (PGT). Until recently, PGT was limited …
[HTML][HTML] An ensemble penalized regression method for multi-ancestry polygenic risk prediction
Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve
the prediction of complex traits and diseases. However, most existing PRS are primarily …
the prediction of complex traits and diseases. However, most existing PRS are primarily …
[HTML][HTML] MUSSEL: enhanced Bayesian polygenic risk prediction leveraging information across multiple ancestry groups
Polygenic risk scores (PRSs) are now showing promising predictive performance on a wide
variety of complex traits and diseases, but there exists a substantial performance gap across …
variety of complex traits and diseases, but there exists a substantial performance gap across …
[PDF][PDF] Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations
Admixed populations, with their unique and diverse genetic backgrounds, are often
underrepresented in genetic studies. This oversight not only limits our understanding but …
underrepresented in genetic studies. This oversight not only limits our understanding but …
Multi-ancestry polygenic risk scores for venous thromboembolism
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality, with
large disparities in incidence rates between Black and White Americans. Polygenic risk …
large disparities in incidence rates between Black and White Americans. Polygenic risk …
[HTML][HTML] Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction
The 313-variant polygenic risk score (PRS 313) provides a promising tool for breast cancer
risk prediction. However, evaluation of the PRS 313 across different European populations …
risk prediction. However, evaluation of the PRS 313 across different European populations …
[PDF][PDF] Power of inclusion: Enhancing polygenic prediction with admixed individuals
Y Tanigawa, M Kellis - The American Journal of Human Genetics, 2023 - cell.com
Admixed individuals offer unique opportunities for addressing limited transferability in
polygenic scores (PGSs), given the substantial trans-ancestry genetic correlation in many …
polygenic scores (PGSs), given the substantial trans-ancestry genetic correlation in many …
[HTML][HTML] Genome wide association study and genomic risk prediction of age related macular degeneration in Israel
The risk of developing age-related macular degeneration (AMD) is influenced by genetic
background. In 2016, the International AMD Genomics Consortium (IAMDGC) identified 52 …
background. In 2016, the International AMD Genomics Consortium (IAMDGC) identified 52 …
Global genomic diversity for All of Us
L Koch - Nature Reviews Genetics, 2024 - nature.com
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