Background Polygenic risk scores (PRS) aggregate the contribution of many risk variants to
provide a personalized genetic susceptibility profile. Since sample sizes of glioma genome …

Background: Several computed tomographic studies have shown the presence of
atherosclerosis in ancient human remains. However, while it is important to understand the …

Background Polygenic risk scores (PRS) quantify an individual's genetic predisposition for
different traits and are expected to play an increasingly important role in personalized …

Over the last 20 years, the field of human genetics has undergone a transformative
revolution, thanks to technological innovations and the power of collaboration, which have …

Mitochondrial DNA (mtDNA) has emerged as a pivotal component in understanding the
etiology and susceptibility of cancer. A recent study by Chen and colleagues delineated the …

Over three percent of people carry a dominant pathogenic mutation, yet only a fraction of
carriers develop disease (incomplete penetrance), and phenotypes from mutations in the …

Background Lung cancer and tobacco use pose significant global health challenges,
necessitating a comprehensive translational roadmap for improved prevention strategies …

Background Lung adenocarcinoma (LUAD) among never-smokers is a public health burden
especially prevalent in East Asian (EAS) women. Polygenic risk scores (PRSs), which …

The disparity in genetic risk prediction accuracy between European and non-European
individuals highlights a critical challenge in health inequality. To bridge this gap, we …

A potential downside is that the protocols designed to assess people's environments and
experiences may query a relatively homogeneous set of experiences that are broadly …