Porcupine O-acyltransferase (PORCN) is considered essential for Wnt secretion and
signaling. However, we observed that PORCN inhibition does not phenocopy the effects of …

The endometrium is a complex and dynamic tissue essential for fertility and implicated in
many reproductive disorders. The tissue consists of glandular epithelium and vascularised …

The WNT family of proteins is crucial in numerous developmental pathways and tissue
homeostasis. WNT4, in particular, is uniquely implicated in the development of the female …

Firstly described at the end of nineteenth century, endometriosis remains an enigmatic
disease, from etiopathogenesis to specific markers of diagnosis and its ability to associate …

STUDY QUESTION Do genetic effects regulate gene expression in human endometrium?
SUMMARY ANSWER This study demonstrated strong genetic effects on endometrial gene …

Background Wnt signaling is an evolutionarily conserved developmental pathway that is
frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt …

Endometriosis is a complex disease, influenced by genetic factors. Genetic markers
associated with endometriosis exist at chromosome 1p36. 12 and lead to altered expression …

Endometriosis is a common estrogendependent inflammatory disorder that affects 6 to 10%
of women of reproductive age and up to 50% of women with infertility and pelvic pain. 1 …

Endometriosis is associated with changes in long non‑coding RNA (lncRNA) and mRNA
expression, but the exact changes during the implantation window are unknown. Therefore …

Identifying tissue-specific molecular signatures of active regulatory elements is critical to
understanding gene regulatory mechanisms. In this study, transcription start sites (TSS) and …