Although microRNAs (miRNAs) expressed in cumulus cells (CCs) may be used to select
competent oocytes/embryos, only a limited number of such miRNAs has been reported. To …

The common human single nucleotide polymorphism rs3820282 is associated with multiple
phenotypes ranging from gestational length to likelihood of endometriosis and ovarian …

Background The uterine cervix has an important role in female reproductive health, but not
much is known about the genetic determinants of cervical biology and pathology. Genome …

Background Malignant transformation of endometriosis is infrequent at the laparoscopic
trocar site. Although malignant transformation is uncommon, it must be acknowledged in …

Uterine leiomyomata (UL), also known as uterine fibroids, are the most common neoplasms
of the reproductive tract and the primary cause for hysterectomy, leading to considerable …

Endometriosis is an estrogen-dependent, progesterone-resistant, inflammatory disease with
symptoms that include pelvic pain, infertility, and compromised quality of life in millions of …

Background Myopia is one of most common eye diseases in the world and affects 1 in 4
Americans. It is a complex disease caused by both environmental and genetics effects; the …

Phenotypes viewed as distinctive to cancer are often recapitulated in benign disease and
consideration of these diseases can inform our understanding of the cancer …

Background Wnt protein secretion and signaling canonically require the enzyme PORCN,
suggesting PORCN inhibitors can effectively treat Wnt-dependent forms of cancer. We tested …

The extent to which genetic influences on complex traits and disease are mediated by
changes in DNA methylation levels has not been systematically explored. We developed an …