Objective: Despite advances in early diagnosis of lung cancer, most lung cancers are
diagnosed in the advanced stages of the disease. Disorders of microRNA expression are …

Wnt signaling is an evolutionarily conserved developmental pathway that is frequently
hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling …

Pelvic organ prolapse (POP) is a downward descent of one or more of the pelvic organs,
resulting in a protrusion of the vaginal wall and/or uterus. We performed a genome-wide …

Introduction: Identification of metastatic miRNAs and understanding their complex functions
provides prognostic and diagnostic bio markers In this study, the expression of miR-372, fgf …

Background: Wnt protein secretion and signaling canonically require the enzyme PORCN,
suggesting PORCN inhibitors can effectively treat Wnt-dependent forms of cancer. We tested …

The underlying causes for endometriosis remain enigmatic. The disease is defined by the
presence of lesions containing tissue resembling endometrium at sites outside the uterus. 1 …

Advances in genomics have led to discovery of hundreds of mutations causing rare
diseases and thousands of risk loci for complex diseases. As methods developed, I applied …

Endometriosis is a chronic gynaecological disorder that affects one in nine women of
reproductive age. The disease has a complex aetiology with 50% of variation in disease risk …