Pulmonary MRI can now provide high‐resolution images that are sensitive to early disease
and specific to inflammation in cystic fibrosis (CF) lung disease. With specificity and function …

Background MRI of the lung is recommended in a number of clinical indications. Having a
non-radiation alternative is particularly attractive in children and young subjects, or pregnant …

Rationale: We recently demonstrated that triple-combination CFTR (cystic fibrosis
transmembrane conductance regulator) modulator therapy with elexacaftor/tezacaftor …

Pulmonary MRI provides structural and quantitative functional images of the lungs without
ionizing radiation, but it has had limited clinical use due to low signal intensity from the lung …

Abstract Background Therapy with Elexacaftor/Tezacaftor/Ivacaftor (ETI) was recently
approved for adult cystic fibrosis (CF) patients with at least one F508del mutation. However …

Cystic fibrosis (CF) remains the most common fatal hereditary lung disease. The discovery of
the cystic fibrosis transmembrane conductance regulator (CFTR) gene 25 years ago set the …

Rationale: Early onset and progression of lung disease in children with cystic fibrosis (CF)
indicates that sensitive noninvasive outcome measures are needed for diagnostic …

Rationale: Studies demonstrating early structural lung damage in infants and preschool
children with cystic fibrosis (CF) suggest that noninvasive monitoring will be important to …

Rationale: Previous studies showed that lumacaftor–ivacaftor therapy results in partial
rescue of CFTR (cystic fibrosis [CF] transmembrane conductance regulator) activity and a …

Background Among the modalities for lung imaging, proton magnetic resonance imaging
(MRI) has been the latest to be introduced into clinical practice. Its value to replace X-ray …