Recent evidence suggests that inadequate hydration of airway surfaces is a common
mechanism in the pathogenesis of airway mucus obstruction. Inhaled hypertonic saline (HS) …

Purpose To test quantitative functional lung MRI techniques in young adults with cystic
fibrosis (CF) compared to healthy volunteers and to monitor immediate treatment effects of a …

Since lung magnetic resonance imaging (MRI) became clinically available, limited clinical
utility has been suggested for applying MRI to lung diseases. Moreover, clinical applications …

Objectives To determine if morphological non-contrast enhanced magnetic resonance
imaging (MRI) of the lung is sensitive to detect mosaic signal intensity in infants and …

Methods This prospective study was approved by the Ethics Committee of the University of
Heidelberg (S-126/2015). Fifteen patients with CF (mean±SD age, 29.3±9.3 yr) and 20 …

Electrical impedance tomography (EIT) provides global and regional information about
ventilation by means of relative changes in electrical impedance measured with electrodes …

Background Electrical impedance tomography (EIT) delivers information about global and
regional ventilation. Linearity of EIT during tidal breathing is known. We investigated the …

Cystic fibrosis (CF) is a common inherited condition caused by mutations in the gene
encoding the CF transmembrane regulator protein. With increased understanding of the …

Lung involvement in cystic fibrosis (CF) disease continues to be a major life-limiting factor of
this autosomal recessive genetic disorder. Efforts made toward early diagnosis and …

Background In patients with cystic fibrosis (CF), pulmonary structures with high MRI T2
signal intensity relate to inflammatory changes in the lung and bronchi. These areas of …