Bivalent chromatin is defined by the co-occurrence of otherwise opposing H3K4me3 and
H3K27me3 modifications and is typically located at unmethylated promoters of lowly …

Since its initial involvement in numerous neurodegenerative pathologies in 2006, either as a
principal actor or as a cofactor, new pathologies implicating transactive response (TAR) …

Summary Polycomb repressive complex 2 (PRC2) mediates H3K27me3 deposition, which is
thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins to …

RNA has been implicated in the recruitment of chromatin modifiers, and previous studies
have provided evidence in favor and against this idea. RNase treatment of chromatin is …

High-resolution Micro-C maps identified a specialized class of regulatory DNAs termed
'tethering elements'(TEs) in Drosophila. These 300–500-bp elements facilitate specific long …

Polycomb group (PcG) proteins mediate epigenetic silencing of important developmental
genes by modifying histones and compacting chromatin through two major protein …

Abstract Development of multicellular animals requires epigenetic repression by Polycomb
group proteins. The latter assemble in multi-subunit complexes, of which two kinds …

During early development, sea lamprey embryos undergo programmatic elimination of DNA
from somatic progenitor cells in a process termed programmed genome rearrangement …

The chromatin compaction activity of Polycomb group proteins has traditionally been
considered essential for transcriptional repression. However, there is very little information …

Polycomb group (PcG) proteins are a subset of epigenetic factors that are highly conserved
throughout evolution. In mammals, PcG proteins can be classified into two muti-proteins …