Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: implications in …
K Kurose, E Sugiyama, Y Saito - Drug metabolism and …, 2012 - jstage.jst.go.jp
Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …
development time and application review time. The former factor is still an important problem …
Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations
A LLerena, MEG Naranjo… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: The frequency of CYP2D6 alleles, related to either a lack of or increased
enzymatic activity, which may lead to poor metabolism (PM) or ultrarapid metabolism (UM) …
enzymatic activity, which may lead to poor metabolism (PM) or ultrarapid metabolism (UM) …
Population pharmacogenomics: an update on ethnogeographic differences and opportunities for precision public health
Y Zhou, VM Lauschke - Human Genetics, 2022 - Springer
Both safety and efficacy of medical treatment can vary depending on the ethnogeographic
background of the patient. One of the reasons underlying this variability is differences in …
background of the patient. One of the reasons underlying this variability is differences in …
Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions
CT Correia, JP Almeida, PE Santos… - The …, 2010 - nature.com
Little has been reported on the factors, genetic or other, that underlie the variability in
individual response, particularly for autism. In this study we simultaneously explored the …
individual response, particularly for autism. In this study we simultaneously explored the …
High frequency of CYP2D6 ultrarapid metabolizers in Spain: controversy about their misclassification in worldwide population studies
MEG Naranjo, F De Andrés, A Delgado… - The …, 2016 - nature.com
Abstract A high frequency (7–10%) of CYP2D6 ultrarapid metabolizers estimated from the
genotype (gUMs) has been claimed to exist among Spaniards and Southern Europeans …
genotype (gUMs) has been claimed to exist among Spaniards and Southern Europeans …
Interethnic differences in the prevalence of main cardiovascular pharmacogenetic biomarkers
K Mirzaev, S Abdullaev, K Akmalova… - …, 2020 - Taylor & Francis
Background: The aim of this study was to determine the prevalence of CYP2C9, VKORC1,
CYP2C19, ABCB1, CYP2D6 and SLCO1B1 genes polymorphisms among residents of the …
CYP2C19, ABCB1, CYP2D6 and SLCO1B1 genes polymorphisms among residents of the …
Common Genetic Polymorphisms in the ABCB1 Gene Are Associated with Risk of Major Depressive Disorder in Male Portuguese Individuals
Major depressive disorder (MDD) is a highly prevalent disorder, which has been associated
with an abnormal response of the hypothalamus–pituitary–adrenal (HPA) axis. Reports have …
with an abnormal response of the hypothalamus–pituitary–adrenal (HPA) axis. Reports have …
Pilot study for the characterization of pharmacogenetically relevant CYP2D6, CYP2C19 and ABCB1 gene polymorphisms in the Hungarian population
O Rideg, Á Háber, L Botz, F Szücs… - Cell Biochemistry …, 2011 - Wiley Online Library
Polymorphisms of CYP450 metabolizer enzymes and transport proteins play crucial roles in
the inter‐individual variability of drug efficiency. The aim of our study was to predict the …
the inter‐individual variability of drug efficiency. The aim of our study was to predict the …
ПОЛИМОРФИЗМ ГЕНОВ CYР2D6, CYP3A5 И CYP3A4 В ПОПУЛЯЦИЯХ РУССКИХ, ТАТАР И БАШКИР
ОЕ Мустафина, ИА Туктарова, ДД Каримов… - Генетика, 2015 - elibrary.ru
Охарактеризовано распределение частот аллелей и генотипов по полиморфным
локусам rs3892097 (1846G> A) гена CYP2D6, rs776746 (6986A> G) гена CYP3A5 …
локусам rs3892097 (1846G> A) гена CYP2D6, rs776746 (6986A> G) гена CYP3A5 …
Cytochrome P450 polymorphisms with impact in cardiovascular drugs metabolisms in European populations
SL Morais, TFC Gonçalves, C Delerue-Matos… - Human Gene, 2022 - Elsevier
The cytochrome P450 (CYP) enzymes constitute a large polymorphic family that play a huge
role in the metabolism of endogenous compounds and in the metabolization of 70–80% of …
role in the metabolism of endogenous compounds and in the metabolization of 70–80% of …