We analyzed 80 different genomic experiments, and found a positive correlation between
both RNA polymerase II transcription and mRNA degradation with growth rates in yeast …

Surveys of transcription in many organisms have observed widespread expression of RNAs
with no known function, encoded within and between canonical coding genes. The search to …

The 5′ to 3′ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA
degradation as a critical component of the major decaysome. Its deletion in the yeast …

The current understanding of gene expression considers transcription and translation to be
independent processes. Challenging this notion, we found that translation efficiency is …

The FACT complex participates in chromatin assembly and disassembly during transcription
elongation. The yeast mutants affected in the SPT16 gene, which encodes one of the FACT …

Transcription by RNA polymerase II (Pol II), and all RNA polymerases for that matter, may be
understood as comprising two cycles. The first cycle relates to the basic mechanism of the …

Here we employ a set of RNA Polymerase II (Pol II) activity mutants to determine the
consequences of increased or decreased Pol II catalysis on gene expression in …

Spt6 is a transcriptional elongation factor and histone chaperone that reassembles
transcribed chromatin. Genome‐wide H3 mapping showed that Spt6 preferentially maintains …

Understanding the functional connection that occurs for the three nuclear RNA polymerases
to synthesize ribosome components during the ribosome biogenesis process has been the …

Herpesviruses are extremely successful parasites that have evolved over millions of years to
develop a variety of mechanisms to coexist with their hosts and to maintain host-to-host …