Chromatin-dependent regulation of RNA polymerases II and III activity throughout the transcription cycle
A Jordán-Pla, I Gupta, L de Miguel-Jiménez… - Nucleic acids …, 2015 - academic.oup.com
The particular behaviour of eukaryotic RNA polymerases along different gene regions and
amongst distinct gene functional groups is not totally understood. To cast light onto the …
amongst distinct gene functional groups is not totally understood. To cast light onto the …
The importance of controlling mRNA turnover during cell proliferation
S Chávez, J García-Martínez, L Delgado-Ramos… - Current genetics, 2016 - Springer
Microbial gene expression depends not only on specific regulatory mechanisms, but also on
cellular growth because important global parameters, such as abundance of mRNAs and …
cellular growth because important global parameters, such as abundance of mRNAs and …
Nonsense-mediated mRNA decay controls the changes in yeast ribosomal protein pre-mRNAs levels upon osmotic stress
E Garre, L Romero-Santacreu, M Barneo-Munoz… - PLoS …, 2013 - journals.plos.org
The expression of ribosomal protein (RP) genes requires a substantial part of cellular
transcription, processing and translation resources. Thus, the RP expression must be tightly …
transcription, processing and translation resources. Thus, the RP expression must be tightly …
[HTML][HTML] One step back before moving forward: regulation of transcription elongation by arrest and backtracking
F Gómez-Herreros, L de Miguel-Jiménez… - FEBS letters, 2012 - Elsevier
RNA polymerase II backtracking is a well-known phenomenon, but its involvement in gene
regulation is yet to be addressed. Structural studies into the backtracked complex, new …
regulation is yet to be addressed. Structural studies into the backtracked complex, new …
TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress
F Gomez-Herreros, L de Miguel-Jimenez… - Nucleic acids …, 2012 - academic.oup.com
Transcription factor IIS (TFIIS) stimulates RNA cleavage by RNA polymerase II by allowing
backtracked enzymes to resume transcription elongation. Yeast cells do not require TFIIS for …
backtracked enzymes to resume transcription elongation. Yeast cells do not require TFIIS for …
Dynamic remodeling of histone modifications in response to osmotic stress in Saccharomyces cerevisiae
L Magraner-Pardo, V Pelechano, MD Coloma… - BMC genomics, 2014 - Springer
Background Specific histone modifications play important roles in chromatin functions; ie,
activation or repression of gene transcription. This participation must occur as a dynamic …
activation or repression of gene transcription. This participation must occur as a dynamic …
Contributions of transcription and mRNA decay to gene expression dynamics of fission yeast in response to oxidative stress
The cooperation of transcriptional and post-transcriptional levels of control to shape gene
regulation is only partially understood. Here we show that a combination of two simple and …
regulation is only partially understood. Here we show that a combination of two simple and …
There is a steady‐state transcriptome in exponentially growing yeast cells
V Pelechano, JE Pérez‐Ortín - Yeast, 2010 - Wiley Online Library
The growth of yeast cells in batches in glucose‐based media is a standard condition in most
yeast laboratories. Most gene expression experiments are done by taking this condition as a …
yeast laboratories. Most gene expression experiments are done by taking this condition as a …
Genome-wide studies of mRNA synthesis and degradation in eukaryotes
JE Pérez-Ortín, L de Miguel-Jiménez… - Biochimica et Biophysica …, 2012 - Elsevier
In recent years, the use of genome-wide technologies has revolutionized the study of
eukaryotic transcription producing results for thousands of genes at every step of mRNA life …
eukaryotic transcription producing results for thousands of genes at every step of mRNA life …
The distribution of active RNA polymerase II along the transcribed region is gene-specific and controlled by elongation factors
A Rodríguez-Gil, J García-Martínez… - Nucleic acids …, 2010 - academic.oup.com
In order to study the intragenic profiles of active transcription, we determined the relative
levels of active RNA polymerase II present at the 3′-and 5′-ends of 261 yeast genes by …
levels of active RNA polymerase II present at the 3′-and 5′-ends of 261 yeast genes by …