Using a combination of in vitro biochemistry, genetics, and genomics, McCullough and
Pham et al. explore how the histone: DNA contact at the entry/exit site of nucleosomes …

Gene expression regulation by intracellular stimulus-activated protein kinases is essential
for cell adaptation to environmental changes. There are three PKA catalytic subunits in …

Spn1/Iws1 plays essential roles in the regulation of gene expression by RNA polymerase II
(RNAPII), and it is highly conserved in organisms ranging from yeast to humans. Spn1 …

Background Gene transcription is regulated by DNA transcriptional regulatory elements,
promoters and enhancers that are located outside the coding regions. Here, we examine the …

Genetically engineering microorganisms to produce chemicals has changed the
industrialized world. The budding yeast Saccharomyces cerevisiae is frequently used in …

Ribosome assembly requires the concerted expression of hundreds of genes, which are
transcribed by all three nuclear RNA polymerases. Transcription elongation involves …

Rapamycin is an anticancer agent and immunosuppressant that acts by inhibiting the TOR
signaling pathway. In yeast, rapamycin mediates a profound transcriptional response for …

Elongation speed is a key parameter in RNA polymerase II (RNA pol II) activity. It affects the
transcription rate, while it is conditioned by the physicochemical environment it works in at …

Under stress conditions, ribosome biogenesis is downregulated. This process requires that
expression of ribosomal RNA, ribosomal protein, and ribosome biogenesis genes be …

Plant-fungi and plant-oomycete interactions have been studied at the proteomic level for
many decades. However, it is only in the last few years, with the development of new …