RNA polymerase II (RNAPII) is a twelve subunit enzyme that catalyzes messenger (mRNA)
in eukaryotic organisms. A number of essential transcription factors associate with RNAPII to …

So far, much attention has been paid to regulation of transcription. However, it has been
realized that controlled mRNA decay is an equally important process. To understand the …

The FACT complex is an essential component of eukaryotic ce... lls able to modify the
chromatin structure allowing transcription by the RNA polymerase II. The FACT that this …

Diamond-Blackfan anemia (DBA) is a rare congenital syndrome that presents with ane-mia
and selective deficiency of erythroid precursors, while other blood lineages are usu-ally …

Grâce à un grand nombre d'études biochimiques, génétiques et structurales effectuées dans
les dernières années, des avancements considérables ont été réalisés et une nouvelle …

Rapamycin is an anticancer agent and immunosuppressant that acts by inhibiting the TOR
signaling pathway. In yeast, rapamycin mediates a profound transcriptional response for …

The model organism Saccharomyces cerevisiae has allowed the development of new
functional genomics techniques devoted to the study of transcription in all its stages. With …

The assessment of transcriptional regulation requires a genome-wide survey of active RNA
polymerases. Thus, we combined the nuclear run-on assay, which labels and captures …

Die zelluläre Reaktion auf DNA-Doppelstrangbrüche (DSBs) ist von enormer Bedeutung für
die Stabilität von Genomen. DSB-Reparatur erfordert die sequentielle Rekrutierung von …

The amount of mRNA in a cell is the result of two opposite reactions: transcription and
mRNA degradation. These reactions are governed by kinetics laws, and the most regulated …