In-silico engineering of RNA nanoplatforms to promote the diabetic wound healing

N Beheshtizadeh, A Salimi, M Golmohammadi… - BMC chemistry, 2023 - Springer
One of the most notable required features of wound healing is the enhancement of
angiogenesis, which aids in the acceleration of regeneration. Poor angiogenesis during …

Molecular link between circadian clocks and cardiac function: a network of core clock, slave clock, and effectors

W Xu, MK Jain, L Zhang - Current opinion in pharmacology, 2021 - Elsevier
Highlights•A network of core clock-slave clock-effectors link the molecular clock to cardiac
function.•The core clock machinery BMAL1: CLOCK regulates circadian rhythm through both …

Vascular endothelial growth factor accelerates healing of foot ulcers in diabetic rats via promoting M2 macrophage polarization

F Liu, X Xu, T Sun - Diabetic Medicine, 2024 - Wiley Online Library
Aim The objective was to investigate the specific role and the regulatory mechanism of
vascular endothelial growth factor (VEGF) during wound healing in diabetic foot ulcer (DFU) …

dECM restores macrophage immune homeostasis and alleviates iron overload to promote DTPI healing

J Zhang, R Si, Y Gao, H Shan, Q Su… - Regenerative …, 2024 - academic.oup.com
Due to its highly insidious and rapid progression, deep tissue pressure injury (DTPI) is a
clinical challenge. Our previous study found that DTPI may be a skeletal muscle injury …

Putative epithelial–mesenchymal transitions during salamander limb regeneration: Current perspectives and future investigations

RT Kim, JL Whited - Annals of the New York Academy of …, 2024 - Wiley Online Library
Previous studies have implicated epithelial–mesenchymal transition (EMT) in salamander
limb regeneration. In this review, we describe putative roles for EMT during each stage of …

In‐Silico Selection of Wound‐Healing Plant Secondary Molecules and Their Pro‐Healing Activities on Experimental Models

O Casadiego, O Macias, L García… - Chemistry & …, 2023 - Wiley Online Library
This study explored the potential of plant‐derived molecules (PDMs) as a medicinal
treatment for skin wounds. To assess their healing properties, 34 potential drug molecules …

竞争性内源性RNA 在创面愈合中作用的研究进展

廖银友, 张丕红 - 中华烧伤与创面修复杂志, 2022 - zhsszz.xml-journal.net
创面愈合作为重要的公共卫生问题之一, 一直是世界性难题. 由于独特的生物创面环境,
创面愈合是一个非常复杂的过程, 目前治疗周期长, 疗效欠佳, 患者经济负担重 …

Transcriptomic analysis of a diabetic skin-humanized mouse model dissects molecular pathways underlying the delayed wound healing response

C León, F García-García, S Llames, E García-Pérez… - Genes, 2020 - mdpi.com
Defective healing leading to cutaneous ulcer formation is one of the most feared
complications of diabetes due to its consequences on patients' quality of life and on the …

[HTML][HTML] Regulating Lars2 in mitochondria: A potential Alzheimer's therapy by inhibiting tau phosphorylation

W Qian, L Yuan, W Zhuge, L Gu, Y Chen, Q Zhuge… - …, 2024 - Elsevier
Driven by the scarcity of effective treatment options in clinical settings, the present study
aimed to identify a new potential target for Alzheimer's disease (AD) treatment. We focused …

Microenvironmental dynamics of diabetic wounds and insights for hydrogel-based therapeutics

Y Zhao, Y Zhao, B Xu, H Liu… - Journal of Tissue …, 2024 - journals.sagepub.com
The rising prevalence of diabetes has underscored concerns surrounding diabetic wounds
and their potential to induce disability. The intricate healing mechanisms of diabetic wounds …