A long noncoding RNA, Kcnq1ot1, regulates the expression of both ubiquitously and tissue-
specific imprinted genes within the Kcnq1 domain. However, the functional sequences of the …

Introduction 3. DNA methylation 3.1. Enzymes associated with dna methylation 3.2. DNA
demethylation 3.3. DNA methylation and gene expression 3.4. DNA methylation, genomic …

Perinatal exposure to diethylstilbestrol (DES) induces reproductive tract cancers later in life
in both humans and animals. Because there is no clear evidence that perinatal DES …

OBJECTIVE: To determine the effect of tamoxifen treatment on global and insulin-like growth
factor 2-H19 imprinting control region (Igf2-H19 ICR)-specific DNA methylation in rat …

Cytochrome aromatase p450, encoded by the gene CYP19, catalyzes the synthesis of
estrogens from androgens. In post-menopausal women, adipose becomes the major site for …

Antisense transcription has been shown to be one of the hierarchies that control gene
expression in eukaryotes. Recently, we have documented that the mouse Kcnq1 imprinting …

Homologous recombination (HR) is established as a significant contributor to double‐strand
break (DSB) repair in mammalian somatic cells; however, its role in mammalian germ cells …

CYP19 is the single copy gene encoding for the estrogen synthetic enzyme aromatase.
Alternate splicing of the promoter is the regulatory mechanism of this gene. In the brain …

Intrauterine exposure to 5-AZA-2′-deoxycytidine (5-AZA-CdR) alters gene expression
causing malformations, abnormal post-natal growth and altered reproductive capacity. To …

We have studied the dynamics of de novo CpG methylation in the regulatory region of one of
the homeobox gene HoxB5 during mouse development by sodium bisulfite sequencing …