Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …

Copper serves as a vital microelement which is widely present in the biosystem, functioning
as multi-enzyme active site, including oxidative stress, lipid oxidation and energy …

Recently, cuproptosis has been demonstrated to be a new non-apototic cell death mode that
is characterized by copper dependence and the regulation of mitochondrial respiration …

The concept of molecular design, integrating diagnostic and therapeutic functions, aligns
with the general trend of modern medical advancement. Herein, we rationally designed the …

Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

Regulated cell death (RCD) is a regulable cell death that involves well-organized signaling
cascades and molecular mechanisms. RCD is implicated in fundamental processes such as …

The endoplasmic reticulum is an important intracellular organelle that plays an important
role in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) and unfolded …

Copper is an essential trace metal for normal cellular functions; a lack of copper is reported
to impair the function of important copper‐binding enzymes, while excess copper could lead …

Emamectin benzoate (EMB) is the most widely used pesticide in the world and contributes to
water pollution. Owing to the lack of a specific antidote, EMB has a severe negative impact …

As an essential nutrient, copper's redox properties are both beneficial and toxic to cells.
Therefore, leveraging the characteristics of copper-dependent diseases or using copper …