Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration

DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Emerging roles of exosomal miRNAs in diabetes mellitus

X He, G Kuang, Y Wu, C Ou - Clinical and translational …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by
almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids …

[HTML][HTML] Mechanism and application of exosomes in the wound healing process in diabetes mellitus

D Li, N Wu - Diabetes Research and Clinical Practice, 2022 - Elsevier
Poor wound healing can seriously affect the health of patients with diabetes and result in a
heavy medical burden. Recently, exosomes have been considered the key substances …

Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system

J Zhang, BA Buller, ZG Zhang, Y Zhang, M Lu… - Experimental …, 2022 - Elsevier
Injury of oligodendrocytes (OLs) induces demyelination, and patients with
neurodegenerative diseases exhibit demyelination concomitantly with neurological deficit …

A comprehensive review on factors influences biogenesis, functions, therapeutic and clinical implications of exosomes

S Gurunathan, MH Kang, JH Kim - International journal of …, 2021 - Taylor & Francis
Exosomes are nanoscale-sized membrane vesicles secreted by almost all cell types into the
extracellular environment upon fusion of multivesicular bodies and plasma membrane …

Gut microbiota modulate distal symmetric polyneuropathy in patients with diabetes

J Yang, X Yang, G Wu, F Huang, X Shi, W Wei… - Cell metabolism, 2023 - cell.com
The pathogenic mechanisms underlying distal symmetric polyneuropathy (DSPN), a
common neuropathy in patients with diabetes mellitus (DM), are not fully understood. Here …

Mesenchymal stem cell–derived exosomes: a promising biological tool in nanomedicine

W Wei, Q Ao, X Wang, Y Cao, Y Liu… - Frontiers in …, 2021 - frontiersin.org
As nano-scale biological vesicles, extracellular vesicles (EVs)/exosomes, in particular,
exosomes derived from mesenchymal stem cells (MSC-exosomes), have been studied in …

Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer's disease

M Guo, Z Yin, F Chen, P Lei - Alzheimer's Research & Therapy, 2020 - Springer
Alzheimer's disease (AD) has been a devastating public health with the development of
global aging. Approaches for reducing the current AD epidemic are becoming a primary …

Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 …

H Ning, H Chen, J Deng, C Xiao, M Xu, L Shan… - Stem Cell Research & …, 2021 - Springer
Background Exosomes are considered a substitute for stem cell-based therapy for
myocardial infarction (MI). FNDC5, a transmembrane protein located in the cytoplasm, plays …