[HTML][HTML] Flaxseed lignans as important dietary polyphenols for cancer prevention and treatment: Chemistry, pharmacokinetics, and molecular targets

SF De Silva, J Alcorn - Pharmaceuticals, 2019 - mdpi.com
Cancer causes considerable morbidity and mortality across the world. Socioeconomic,
environmental, and lifestyle factors contribute to the increasing cancer prevalence …

Modulation of aromatase by phytoestrogens

ED Lephart - Enzyme research, 2015 - Wiley Online Library
The aromatase enzyme catalyzes the conversion of androgens to estrogens in many human
tissues. Estrogens are known to stimulate cellular proliferation associated with certain …

Risk assessment for peri‐and post‐menopausal women taking food supplements containing isolated isoflavones

EFSA Panel on Food Additives and Nutrient … - Efsa …, 2015 - Wiley Online Library
Abstract The EFSA ANS Panel was asked to deliver a scientific opinion on the possible
association between the intake of isoflavones from food supplements and harmful effects on …

An in vitro investigation of endocrine disrupting effects of the mycotoxin alternariol

C Frizzell, D Ndossi, S Kalayou, GS Eriksen… - Toxicology and applied …, 2013 - Elsevier
Alternariol (AOH) is a mycotoxin commonly produced by Alternaria alternata on a wide
range of foods. Few studies to date have been performed to evaluate the effects of AOH on …

Adverse reproductive and developmental health outcomes following prenatal exposure to a hydraulic fracturing chemical mixture in female C57Bl/6 mice

CD Kassotis, JJ Bromfield, KC Klemp, CX Meng… - …, 2016 - academic.oup.com
Unconventional oil and gas operations using hydraulic fracturing can contaminate surface
and groundwater with endocrine-disrupting chemicals. We have previously shown that 23 of …

Soy as an endocrine disruptor: cause for caution?

S Bar-El Dadon, R Reifen - 2010 - degruyter.com
Endocrine disrupting compounds (EDCs) alter the function of the endocrine system and
consequently cause adverse health effects. Phytoestrogens, natural plant compounds …

In vitro bioassays for the study of endocrine-disrupting food additives and contaminants

L Connolly, E Ropstad, S Verhaegen - TrAC Trends in Analytical Chemistry, 2011 - Elsevier
Endocrine-disrupting chemicals (EDCs) are capable of interfering with normal hormone
homeostasis by acting on several targets and through a wide variety of mechanisms …

Beneficial role of biochanin A on cutaneous and renal tissues of ovariectomized rats treated with anastrozole

AAA Galal, AAR Mohamed, SI Khater, MMM Metwally - Life sciences, 2018 - Elsevier
Aims This study was designed to assess the beneficial role of biochanin A (BCA) in the
protection of the cutaneous and renal tissues of ovariectomized rats, even in those treated …

Effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells

D Richter, S Abarzua, M Chrobak… - Nutrition and …, 2013 - Taylor & Francis
Phytoestrogens have a controversial effect on hormone-dependent tumours. Herein, we
investigated the effect of the pumpkin seed extract (PSE) on estradiol production and …

Endocrine disrupting effects of ochratoxin A at the level of nuclear receptor activation and steroidogenesis

C Frizzell, S Verhaegen, E Ropstad, CT Elliott… - Toxicology letters, 2013 - Elsevier
Ochratoxin A (OTA) is a mycotoxin and extrolite of fungi which has been reported in a range
of foods. This study uses mammalian reporter gene assays (RGAs) with natural steroid …