An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …

Genetic and pharmacological interventions have successfully extended healthspan and
lifespan in animals, but their genetic interventions are not appropriate options for human …

Flexible behaviors over long timescales are thought to engage recurrent neural networks in
deep brain regions, which are experimentally challenging to study. In insects, recurrent …

Time-restricted feeding (TRF) has recently gained interest as a potential anti-ageing
treatment for organisms from Drosophila to humans,,,–. TRF restricts food intake to specific …

The gut microbiome is well known to impact host physiology and health. Given widespread
control of physiology by circadian clocks, we asked how the microbiome interacts with …

Excess adipose fat accumulation, or obesity, is a growing problem worldwide in terms of
both the rate of incidence and the severity of obesity-associated metabolic disease. Adipose …

In Drosophila, the fat body (FB), a functional analog of the vertebrate adipose tissue, is the
nutrient sensor that conveys the nutrient status to the insulin-producing cells (IPCs) in the fly …

The progressive loss of muscle strength during aging is a common degenerative event of
unclear pathogenesis. Although muscle functional decline precedes age-related changes in …

Endogenous circadian rhythms are thought to modulate responses to external factors, but
mechanisms that confer time-of-day differences in organismal responses to environmental …

The incidence of the metabolic syndrome represents a spectrum of disorders that continue to
increase across the industrialized world. Both genetic and environmental factors contribute …