The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Neuroinflammation is instigated by the misfiring of immune cells in the central nervous
system (CNS) involving microglia and astrocytes as key cell-types. Neuroinflammation is a …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

Noncanonical functions of the autophagy machinery in pathways including LC3-associated
phagocytosis and LC3-associated endocytosis have garnered increasing interest in both …

Autophagy refers to the formation of autophagosomes by membrane wrapping part of the
cytoplasm and the organelles and proteins that need to be degraded in the cells …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …

As a key component of the inflammasome, NLRP3 is a critical intracellular danger sensor
emerging as an important clinical target in inflammatory diseases. However, little is known …

Neurodegenerative disorders are characterized by the progressive dysfunction and death of
selectively vulnerable neuronal populations, often associated with the accumulation of …

Neuroinflammation is considered as a detrimental factor in neurodegenerative diseases,
including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) …

The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …