[HTML][HTML] Animal models of Klebsiella pneumoniae mucosal infections

L Assoni, AJM Couto, B Vieira, B Milani… - Frontiers in …, 2024 - frontiersin.org
Klebsiella pneumoniae is among the most relevant pathogens worldwide, causing high
morbidity and mortality, which is worsened by the increasing rates of antibiotic resistance. It …

Heptavalent O-Antigen Bioconjugate Vaccine Exhibiting Differential Functional Antibody Responses Against Diverse Klebsiella pneumoniae Isolates

PL Wantuch, CJ Knoot, LS Robinson… - The Journal of …, 2024 - academic.oup.com
Klebsiella pneumoniae is the leading cause of neonatal sepsis and is increasingly difficult to
treat owing to antibiotic resistance. Vaccination represents a tractable approach to combat …

A novel antivirulent compound fluorothiazinone inhibits Klebsiella pneumoniae biofilm in vitro and suppresses model pneumonia

SV Tsarenko, NA Zigangirova, AV Soloveva… - The Journal of …, 2023 - nature.com
The problematic treatment of infections caused by multiple-resistant Klebsiella, especially in
ICU, is the leading cause of prolonged hospitalization and high mortality rates. The use of …

Polyamine-Mediated Sensitization of Klebsiella pneumoniae to Macrolides through a Dual Mode of Action

JME Adams, PB Moulding… - ACS Infectious …, 2024 - ACS Publications
Chemicals bacteria encounter at the infection site could shape their stress and antibiotic
responses; such effects are typically undetected under standard lab conditions. Polyamines …

Differentiation of hypervirulent and classical Klebsiella pneumoniae with acquired drug resistance

TA Russo, CL Alvarado, CJ Davies, ZJ Drayer… - Mbio, 2024 - Am Soc Microbiol
Distinguishing hypervirulent (hvKp) from classical Klebsiella pneumoniae (cKp) strains is
important for clinical care, surveillance, and research. Some combinations of iucA, iroB, peg …

[HTML][HTML] Polyproline peptide targets Klebsiella pneumoniae polysaccharides to collapse biofilms

L De los Santos, RL Beckman, C DeBarro… - Cell Reports Physical …, 2024 - cell.com
Hypervirulent Klebsiella pneumoniae is known for its increased extracellular polysaccharide
production. Biofilm matrices of hypervirulent K. pneumoniae have increased polysaccharide …

Molecular characterization and virulence profile of Klebsiella pneumoniae and Klebsiella oxytoca isolated from ill cats and dogs in Portugal

J Castro, R Oliveira, L Fernandes, I Carvalho… - Veterinary …, 2024 - Elsevier
Klebsiella spp. are important pathogens of humans and companion animals such as cats
and dogs, capable of causing severe life-threatening diseases. The aim of this study was to …

Emergence of novel non-aggregative variants under negative frequency-dependent selection in Klebsiella variicola

A Nucci, J Janaszkiewicz, EPC Rocha, O Rendueles - Microlife, 2023 - academic.oup.com
Klebsiella variicola is an emergent human pathogen causing diverse infections, some of
which in the urinary tract. However, little is known about the evolution and maintenance of …

Genome Sequence and Characterization of Coliphage Môr Ffagbaw

NE Thomas, NI Ugokwe, A Kinsella, E Galyov… - PHAGE, 2023 - liebertpub.com
Background: The quality of coastal waters around the United Kingdom is an area of
increasing concern following sewer overflow, where wastewater is discharged into the …

[HTML][HTML] Genomic insights into in-ICU emergence of last-resort antimicrobial resistance in a rare, carbapenem resistant, ST16 Klebsiella pneumoniae strain from …

A Chakrabortty, A Kapoor, T Dey, SS Khochare… - Journal of Global …, 2024 - Elsevier
Objectives To investigate the genomic differences between two extensively drug resistant,
ST16 strains of Klebsiella pneumoniae recovered from patients in the same ICU, one of …