Protein misfolding and aggregation are characteristic of a wide range of neurodegenerative
disorders, including Alzheimer and Parkinson diseases. A hallmark of these diseases is the …

Aptamers are single-stranded oligonucleotides (RNA or DNA) with a typical length between
25 and 100 nucleotides which fold into three-dimensional structures capable of binding to …

The α-synuclein aggregates are the main component of Lewy bodies in Parkinson's disease
(PD) brain, and they showed immunotherapy could be employed to alleviate α-synuclein …

Alzheimer's disease (AD) is an irreversible neurodegenerative disease, causing profound
social and economic implications. Early diagnosis and treatment of AD have faced great …

Aptamers are oligonucleotides selected from large pools of random sequences based on
their affinity for bioactive molecules and are used in similar ways to antibodies. Aptamers …

The composition of soluble toxic protein aggregates formed in vivo is currently unknown in
neurodegenerative diseases, due to their ultra-low concentration in human biofluids and …

Abstract Changes in amyloid-beta-oligomer (AβΟ) peptides levels are considered one of the
major neuropathologic biomarkers for Alzheimer's Disease (AD). AβΟ levels can be …

Alzheimer's disease (AD) is an obvious neurological disorder characterized by progressive
brain cell death that resulted in memory loss, cognitive decline, and finally dementia …

The development of cost-efficient, sensitive and specific methods to detect amyloid-beta 42
(Aβ42) biomarkers in cerebrospinal fluid and serum-samples is of considerable interest to …

Amyloid plaques are one of the two hallmarks of Alzheimer's disease (AD). They consist
mainly of fibrils made of self-assembled amyloid-β (Aβ) peptides. Aβ is produced in healthy …