The very first line of defense in humans is innate immunity, serving as a critical strongpoint in
the regulation of inflammation. Abnormalities of the innate immunity machinery make up a …

Recurrent self-limited attacks of fever and short-lived inflammation in the serosal
membranes, joints, and skin are the leading features of familial Mediterranean fever (FMF) …

Cellular lipid requirements are achieved through a combination of biosynthesis and import
programs. Using isotope tracer analysis, we show that type I interferon (IFN) signaling shifts …

Introduction: Hallmark of autoinflammatory syndromes (AIS) is the periodic recurrence of
'sterile'inflammatory attacks characterized by fever and organ-or tissue-specific …

Innate immunity is a critical partner in the regulation of inflammation and some mutations in
genes implied in innate immunity pathways can cause genetic disorders characterized by …

The innate immunity works as a defence bullwark that safeguards healthy tissues with the
power of detecting infectious agents in the human body: errors in the context of innate …

Systemic autoinflammatory disorders (SAIDs) are inherited defects of innate immunity
characterized by recurrent sterile inflammatory attacks involving skin, joints, serosal …

A disparate group of rare hematological diseases characterized by impaired maturation of
neutrophil granulocytes defines congenital neutropenias. Neutropenic patients are prone to …

Monogenic autoinflammatory diseases (mAIDs) are inherited errors of innate immunity
characterized by systemic inflammation recurring with variable frequency and involving the …

The activation of the pyrin inflammasome represents a highly intriguing mechanism
employed by the innate immune system to effectively counteract pathogenic agents. Despite …