The Kelch-like ECH associated protein 1 (Keap1) is a component of a Cullin3-based Cullin-
RING E3 ubiquitin ligase (CRL) multisubunit protein complex. Within the CRL, homodimeric …

Redox imbalance and persistent inflammation are the underlying causes of most chronic
diseases. Mammalian cells have evolved elaborate mechanisms for restoring redox …

Reactive oxygen species (ROS) play an important role in cell proliferation and
differentiation. They are also by-products of aerobic living conditions. Their inherent …

The ability of viruses to subvert host pathways is central in disease pathogenesis. Over the
past decade, a critical role for the Ubiquitin Proteasome System (UPS) in counteracting host …

Cullin-Ring ubiquitin ligases regulate protein turnover by promoting the ubiquitination of
substrate proteins, targeting them for proteasomal degradation. It has been shown …

Appropriate axon guidance is necessary to form accurate neuronal connections. Axon
guidance cues that stimulate cytoskeletal reorganization within the growth cone direct axon …

The study of rare monogenic forms of hypertension has led to the elucidation of important
physiological pathways controlling blood pressure. Mutations in several genes cause …

Phosphatidylinositol 3-kinase α, a heterodimer of catalytic p110α and one of five regulatory
subunits, mediates insulin-and insulin like growth factor-signaling and, frequently …

Ligand activation of the angiotensin II type 1 receptor (AT1R), a member of the G protein‐
coupled receptor (GPCR) family, stimulates intracellular signaling to mediate a variety of …

Transcription is regulated through a dynamic interplay of DNA-associated proteins, and the
composition of gene-regulatory complexes is subject to continuous adjustments. Protein …