[HTML][HTML] On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability

AN Khristich, SM Mirkin - Journal of Biological Chemistry, 2020 - ASBMB
Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …

Non-B DNA structure-induced genetic instability and evolution

J Zhao, A Bacolla, G Wang, KM Vasquez - Cellular and molecular life …, 2010 - Springer
Repetitive DNA motifs are abundant in the genomes of various species and have the
capacity to adopt non-canonical (ie, non-B) DNA structures. Several non-B DNA structures …

Short-sequence DNA repeats in prokaryotic genomes

A Van Belkum, S Scherer, L Van Alphen… - Microbiology and …, 1998 - Am Soc Microbiol
Short-sequence DNA repeat (SSR) loci can be identified in all eukaryotic and many
prokaryotic genomes. These loci harbor short or long stretches of repeated nucleotide …

Replication fork stalling at natural impediments

EV Mirkin, SM Mirkin - Microbiology and molecular biology …, 2007 - Am Soc Microbiol
Accurate and complete replication of the genome in every cell division is a prerequisite of
genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely …

Variable human minisatellite‐like regions in the Mycobacterium tuberculosis genome

P Supply, E Mazars, S Lesjean, V Vincent… - Molecular …, 2000 - Wiley Online Library
Mycobacterial interspersed repetitive units (MIRUs) are 40–100 bp DNA elements often
found as tandem repeats and dispersed in intergenic regions of the Mycobacterium …

Selection against frameshift mutations limits microsatellite expansion in coding DNA

D Metzgar, J Bytof, C Wills - Genome research, 2000 - genome.cshlp.org
Microsatellite enrichment is an excess of repetitive sequences characteristic to all studied
eukaryotes. It is thought to result from the accumulated effects of replication slippage …

Computational and experimental characterization of physically clustered simple sequence repeats in plants

L Cardle, L Ramsay, D Milbourne, M Macaulay… - Genetics, 2000 - academic.oup.com
The type and frequency of simple sequence repeats (SSRs) in plant genomes was
investigated using the expanding quantity of DNA sequence data deposited in public …

Replication stalling at unstable inverted repeats: interplay between DNA hairpins and fork stabilizing proteins

I Voineagu, V Narayanan… - Proceedings of the …, 2008 - National Acad Sciences
DNA inverted repeats (IRs) are hotspots of genomic instability in both prokaryotes and
eukaryotes. This feature is commonly attributed to their ability to fold into hairpin-or cruciform …

Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business

JE Wedekind, GSC Dance, MP Sowden, HC Smith - Trends in Genetics, 2003 - cell.com
Alteration of mRNA sequence through base modification mRNA editing frequently generates
protein diversity. Several proteins have been identified as being similar to C-to-U mRNA …

Trinucleotide repeats affect DNA replication in vivo

GM Samadashwily, G Raca, SM Mirkin - Nature genetics, 1997 - nature.com
Abstract (CGG) n (CCG) n and (CTG) n (CAG) n repeats of varying length were cloned into a
bacterial plasmid, and the progression of the replication fork through these repeats was …