Advances in the diagnosis and treatment of Clostridium difficile infections

Z Peng, L Ling, CW Stratton, C Li… - Emerging microbes & …, 2018 - Taylor & Francis
Clostridium difficile is a leading cause of antibiotic-associated diarrhea worldwide. The
diagnosis of C. difficile infection (CDI) requires both clinical manifestations and a positive …

Evolutionary and Genomic Insights into Clostridioides difficile Sequence Type 11: a Diverse Zoonotic and Antimicrobial-Resistant Lineage of Global One Health …

DR Knight, B Kullin, GO Androga, F Barbut, C Eckert… - MBio, 2019 - Am Soc Microbiol
Clostridioides difficile (Clostridium difficile) sequence type 11 (ST11) is well established in
production animal populations worldwide and contributes considerably to the global burden …

[HTML][HTML] Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children

Z Ling, X Liu, X Jia, Y Cheng, Y Luo, L Yuan, Y Wang… - Scientific reports, 2014 - nature.com
Increasing evidence suggests that altered intestinal microbial composition and function
result in an increased risk of Clostridium difficile-associated diarrhoea (CDAD); however, the …

Emergence and Spread of Epidemic Multidrug-Resistant Pseudomonas aeruginosa

T Miyoshi-Akiyama, T Tada, N Ohmagari… - Genome biology and …, 2017 - academic.oup.com
Pseudomonas aeruginosa (P. aeruginosa) is one of the most common nosocomial
pathogens worldwide. Although the emergence of multidrug-resistant (MDR) P. aeruginosa …

[HTML][HTML] Mechanistic insights in the success of fecal microbiota transplants for the treatment of Clostridium difficile infections

A Baktash, EM Terveer, RD Zwittink… - Frontiers in …, 2018 - frontiersin.org
Fecal microbiota transplantation has proven to be an effective treatment for infections with
the gram-positive enteropathogen Clostridium difficile. Despite its effectiveness, the exact …

Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance

MR Davies, MT Holden, P Coupland, JHK Chen… - Nature …, 2015 - nature.com
A scarlet fever outbreak began in mainland China and Hong Kong in 2011 (refs.–).
Macrolide-and tetracycline-resistant Streptococcus pyogenes emm 12 isolates represent the …

The evolutionary puzzle of Escherichia coli ST131

JDD Pitout, TJ Finn - Infection, Genetics and Evolution, 2020 - Elsevier
The abrupt expansion of Escherichia coli sequence type (ST) 131 is unmatched among
Gram negative bacteria. In many ways, ST131 can be considered a real-world model for the …

Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing

EJ Klemm, VK Wong, G Dougan - Proceedings of the …, 2018 - National Acad Sciences
Antibiotic resistance in bacteria has emerged as a global challenge over the past 90 years,
compromising our ability to effectively treat infections. There has been a dramatic increase in …

Gut bacteria are rarely shared by co-hospitalized premature infants, regardless of necrotizing enterocolitis development

T Raveh-Sadka, BC Thomas, A Singh, B Firek… - Elife, 2015 - elifesciences.org
Premature infants are highly vulnerable to aberrant gastrointestinal tract colonization, a
process that may lead to diseases like necrotizing enterocolitis. Thus, spread of potential …

Current application and future perspectives of molecular typing methods to study Clostridium difficile infections

CW Knetsch, TD Lawley, MP Hensgens… - …, 2013 - eurosurveillance.org
Molecular typing is an essential tool to monitor Clostridium difficile infections and outbreaks
within healthcare facilities. Molecular typing also plays a key role in defining the regional …