In this review, we outline recent advancements in small molecule drug design from a
structural perspective. We compare protein structure prediction methods and explore the …

Mutations in the photoreceptor-specific C2orf71 gene (also known as photoreceptor cilium
actin regulator protein PCARE) cause autosomal recessive retinitis pigmentosa type 54 and …

Blindness poses a growing global challenge, with approximately 26% of cases attributed to
degenerative retinal diseases. While gene therapy, optogenetic tools, photosensitive …

Organoids are three-dimensional cellular structures designed to recreate the biological
characteristics of the body's native tissues and organs in vitro. There has been a recent …

Neuromuscular disorders caused by dysfunction of the mitochondrial respiratory chain are
common, severe and untreatable. We recovered a number of mitochondrial genes, including …

Macroautophagy is a lysosomal degradative pathway for intracellular macromolecules,
protein aggregates, and organelles. The formation of the autophagosome, a double …

Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration
and impose a considerable economic burden on patients and society, making efforts to cure …

Chronic elevation of blood glucose at first causes relatively minor changes to the neural and
vascular components of the retina. As the duration of hyperglycemia persists, the nature and …

The human photoreceptor function is dependent on a highly specialised cilium. Perturbation
of cilial function can often lead to death of the photoreceptor and loss of vision. Retinal …

The retina is part of the central nervous system specialized for vision. Inherited retinal
diseases (IRD) are a group of clinically and genetically heterogenous disorders that lead to …