The multiple sclerosis prodrome

N Makhani, H Tremlett - Nature Reviews Neurology, 2021 - nature.com
A prodrome is an early set of signs, symptoms or other findings that occur before the onset of
typical symptoms of a disease. Prodromal phases are well recognized in several …

Environmental risk factors in multiple sclerosis aetiology

RA Marrie - The Lancet Neurology, 2004 - thelancet.com
The epidemiology of multiple sclerosis (MS) has been intensively studied. It is
conceptualised as a complex disease in which genetic and environmental factors act …

Disability progression in multiple sclerosis is slower than previously reported

H Tremlett, D Paty, V Devonshire - Neurology, 2006 - AAN Enterprises
Objective: To investigate disease progression and risk factors in a large geographically
based population with multiple sclerosis (MS), using two different inception points—clinical …

Increased risk for demyelinating diseases in patients with inflammatory bowel disease

G Gupta, JM Gelfand, JD Lewis - Gastroenterology, 2005 - Elsevier
Background & Aims: Reports of multiple sclerosis (MS), demyelination, and optic neuritis
(ON) associated with anti–tumor necrosis factor α therapy resulted in warnings on …

The multiple sclerosis prodrome: Emerging evidence, challenges, and opportunities

H Tremlett, RA Marrie - Multiple Sclerosis Journal, 2021 - journals.sagepub.com
A prodrome is considered an early set of signs or symptoms indicating the onset of a
disease or illness. In multiple sclerosis (MS), the prodromal period is the months or years …

How does age at onset influence the outcome of autoimmune diseases?

MJ Amador-Patarroyo… - Autoimmune …, 2012 - Wiley Online Library
The age at onset refers to the time period at which an individual experiences the first
symptoms of a disease. In autoimmune diseases (ADs), these symptoms can be subtle but …

Is late-onset multiple sclerosis associated with a worse outcome?

H Tremlett, V Devonshire - Neurology, 2006 - AAN Enterprises
Objective: To describe the characteristics of late-onset multiple sclerosis (MS)(LOMS, 50+
years) vs adult-onset MS (AOMS, 16 to< 50 years) and examine prognosis and associated …

Environmental risk factors in multiple sclerosis

M Pugliatti, HF Harbo, T Holmøy… - Acta Neurologica …, 2008 - Wiley Online Library
Objectives–Multiple sclerosis (MS) likely results from an interaction between genetic and
exogenous factors. While genetics shapes the overall population MS susceptibility …

Age at onset in multiple sclerosis

M Ligouri, MG Marrosu, M Pugliatti, F Giuliani… - Neurological …, 2000 - Springer
Age at onset of multiple sclerosis (MS) can vary from childhood to adult life. Many reports
have been carried out over the years concerning the role of age at onset in determining the …

Multiple sclerosis in the elderly patient

A Awad, O Stüve - Drugs & aging, 2010 - Springer
Multiple sclerosis (MS) is an acquired inflammatory demyelinating disease of the CNS that is
typically diagnosed in the second or third decade of life. It is generally believed that over the …