Stochastic protein accumulation up to some concentration threshold sets the timing of many
cellular physiological processes. Here we obtain the exact distribution of first threshold …

Cells are the fundamental units of life, and like all life forms, they change over time. Changes
in cell state are driven by molecular processes; of these many are initiated when molecule …

Many cellular events occur when their corresponding regulatory proteins attain critical
thresholds. Can cells schedule such events with precision by controlling the dynamics of the …

We derive universal thermodynamic inequalities that bound from below the moments of first-
passage times of stochastic currents in nonequilibrium stationary states of Markov jump …

An important function of microRNAs in gene regulation is to repress the protein synthesis in
a multi-step process with implications in timing efficiency of the regulatory network. We …

The timing of biochemical events is often determined by the accumulation of a protein or
chemical species to a critical threshold level. In a stochastic model, we define event timing …

For cell division to take place, proteins that carry it out need to accumulate to a functional
threshold. Most of these divisome proteins are highly abundant in the cell, and accumulate …

We derive generic thermodynamic bounds on the moments of first-passage times of
dissipative currents in nonequilibrium stationary states. These bounds hold generically for …

Expressed gene products often interact ubiquitously with binding sites at nucleic acids and
macromolecular complexes, known as decoys. Binding of transcription factors (TFs) to …

Changes in cell state are driven by key molecular events whose timing can often be
measured experimentally. Of particular interest is the time taken for the levels of RNA or …