A high number of co-occurring genomic alterations detected by NGS is associated with worse clinical outcomes in advanced EGFR-mutant lung adenocarcinoma …

D Heredia, L Mas, AF Cardona, V Oyervides… - Lung Cancer, 2022 - Elsevier
Background Co-occurring genomic alterations identified downstream main oncogenic
drivers have become more evident since the introduction of next-generation sequencing …

Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells

F Gao, M Li, X Yu, W Liu, L Zhou… - Journal of Cellular and …, 2021 - Wiley Online Library
Dysfunction of epidermal growth factor receptor (EGFR) signalling plays a critical role in the
oncogenesis of non–small‐cell lung cancer (NSCLC). Here, we reported the natural product …

[HTML][HTML] Synthesis and Biological Properties of EGFR-Targeted Photosensitizer Based on Cationic Porphyrin

YS Bortnevskaya, NA Shiryaev, NS Zakharov… - Pharmaceutics, 2023 - mdpi.com
Photodynamic therapy (PDT) in oncology is characterized by low invasiveness, minimal side
effects, and little tissue scarring. Increasing the selectivity of PDT agents toward a cellular …

[HTML][HTML] Modern therapies of nonsmall cell lung cancer

A Jachowski, M Marcinkowski, J Szydłowski… - Journal of Applied …, 2023 - Springer
Lung cancer (LC), particularly nonsmall cell lung cancer (NSCLC), is one of the most
prevalent types of neoplasia worldwide, regardless of gender, with the highest mortality …

[HTML][HTML] Exosome-derived circKIF20B suppresses gefitinib resistance and cell proliferation in non-small cell lung cancer

SL Wei, JJ Ye, L Sun, L Hu, YY Wei, DW Zhang… - Cancer Cell …, 2023 - Springer
Background The gefitinib resistance mechanism in non-small cell lung cancer (NSCLC)
remains unclear, albeit exosomal circular RNA (circRNA) is known to possibly play a vital …

A pharmacological exploration of targeted drug therapy in non-small cell lung cancer

AP Jayan, KR Anandu, K Madhu, VN Saiprabha - Medical Oncology, 2022 - Springer
Lung cancer is the prime cause of cancer-related deaths globally, with a contribution of 85%
from non-small cell lung cancer. Before a few decades back, conventional chemotherapy …

Advanced Non-small Cell Lung Cancer: EGFR Mutation Analysis Using Pyrosequencing and the Fully Automated qPCR-Based IdyllaTM System

Y Boustany, A Laraqui, S El Zaitouni… - Cancer …, 2023 - journals.sagepub.com
Background Epidermal growth factor receptor (EGFR) mutation status is of a major clinical
significance in non-small cell lung cancer (NSCLC) management, as it guides therapeutic …

First-Line Afatinib plus Cetuximab for EGFR-Mutant Non–Small Cell Lung Cancer: Results from the Randomized Phase II IFCT-1503 ACE-Lung Study

AB Cortot, A Madroszyk, E Giroux-Leprieur… - Clinical Cancer …, 2021 - AACR
Purpose: Double inhibition of epidermal growth factor receptor (EGFR) using a tyrosine
kinase inhibitor plus a monoclonal antibody may be a novel treatment strategy for non–small …

[HTML][HTML] A multicenter retrospective study on the prognosis of stage III unresectable mutant non-small cell lung cancer with tyrosine kinase inhibitors therapy

R Wu, S Yu, J Ye, Y Wang, Z Zhao, H Liu… - Frontiers in …, 2021 - frontiersin.org
Background For unresectable stage III non-small cell lung cancer (NSCLC), concurrent
chemoradiotherapy is nowadays the standard treatment. Patients with advanced NSCLC …

Cost‐effectiveness analysis of first‐line treatments for advanced epidermal growth factor receptor‐mutant non‐small cell lung cancer patients

WQ Li, LY Li, J Chai, JW Cui - Cancer Medicine, 2021 - Wiley Online Library
Objectives Recent studies showed prolonged survival for advanced epidermal growth factor
receptor (EGFR)‐mutant non‐small cell lung cancer (NSCLC) patients treated with both …