The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Sepsis is the leading cause of death in critically ill patients in the United States. Yet the
individual host response to septicemia is variable, depending on the patient's immune …

Objectives: To provide an appraisal of the evolving paradigms in the pathophysiology of
sepsis and propose the evolution of a new phenotype of critically ill patients, its potential …

Ageing is a complex process that negatively impacts the development of the immune system
and its ability to function. The mechanisms that underlie these age‐related defects are broad …

Although the prevailing concept has been that mortality in sepsis results from an unbridled
hyper-inflammatory cytokine-mediated response, the failure of more than 30 clinical trials to …

Novel strategies for the treatment of sepsis | Nature Medicine Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To …

Sepsis remains a critical problem with significant morbidity and mortality even in the modern
era of critical care management. Multiple derangements exist in sepsis involving several …

The importance of the macrophage in innate immunity is underscored by its secretion of an
array of powerful immunoregulatory and effector molecules. We report herein that …

Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the
disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving …

Sepsis is a highly lethal disorder characterized by widespread apoptosis-induced depletion
of immune cells and the development of a profound immunosuppressive state. IL-7 is a …